Components of diesel exhaust particles diversely enhance a variety of respiratory diseases related to infection or allergy: extracted organic chemicals and the residual particles after extraction differently affect respiratory diseases.
Components of diesel exhaust particles diversely enhance a variety of respiratory diseases related to infection or allergy: extracted organic chemicals and the residual particles after extraction differently affect respiratory diseases.
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DOI：
10.3164/jcbn.40.101
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发表时间：
2007-03
影响因子：
2.4
通讯作者：
Inoue K
中科院分区：
文献类型：
--
作者：
Takano H;Yanagisawa R;Inoue K
实验和流行病学研究表明，柴油机尾气颗粒物（DEP）可加重多种呼吸道疾病，包括感染或过敏。然而，尚未确定DEP中负责增强的组件。本文综述了DEP各组分对与感染或变态反应相关的呼吸道疾病的不同作用。我们将小鼠暴露于有机化学品（DEP-OC）和残留的碳质核（洗涤DEP）来自DEP的存在或不存在的细菌内毒素（脂多糖：LPS）或过敏原。在我们的第一系列实验中，洗涤的DEP与LPS组合协同加重肺损伤，这伴随着促炎细胞因子和趋化因子的肺表达增强，而DEP-OC与LPS组合则没有。相比之下，我们的第二系列实验表明，DEP-OC，而不是洗涤DEP，增强过敏原相关的嗜酸性粒细胞炎症和气道上皮中杯状细胞的增殖，这是由增强的肺表达的嗜酸性粒细胞趋化因子和白细胞介素-5。而用卵清蛋白洗涤的DEP变化较小，并增加了肺γ-干扰素的表达。结果表明，DEP组分对多种呼吸系统疾病均有不同程度的影响，而有机化合物与碳核的结合（全DEP）则主要加重呼吸系统疾病。
Experimental and epidemiological studies have reported that diesel exhaust particles (DEP) can aggravate a variety of respiratory diseases including infection or allergy. However, the responsible components in DEP for the enhancement have not been identified. The present review demonstrates the different effects of the components of DEP on the respiratory diseases related to infection or allergy. We exposed mice to the organic chemicals (DEP-OC) and the residual carbonaceous nuclei (washed DEP) derived from DEP in the presence or absence of bacterial endotoxin (lipopolysaccharide: LPS) or allergen. In our first series of experiments, washed DEP combined with LPS synergistically exacerbated lung injury, which was concomitant with the enhanced lung expression of proinflammatory cytokines and chemokines, whereas DEP-OC combined with LPS did not. In contrast, our second series of experiments showed that DEP-OC, rather than washed DEP, enhanced allergen-related eosinophilic inflammation and proliferation of goblet cells in the airway epithelium, which was paralleled by the enhanced lung expression of eotaxin and interleukin-5. However, washed DEP with ovalbmin showed less change and increased the lung expression of interferon-γ. It is suggested that DEP components diversely affect various types of respiratory diseases, while the combination of organic chemicals and carbonaceous nuclei (whole DEP) mostly aggravate respiratory diseases.
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影响因子：
4.5
作者：
Ichinose, T;Takano, H;Sagai, M
通讯作者：
Sagai, M
影响因子：
8.3
作者：
SCHWARTZ, J
通讯作者：
SCHWARTZ, J
DOI：
10.1164/rccm.2108122
发表时间：
2002-05-01
影响因子：
24.7
作者：
Takano, H;Yanagisawa, R;Morita, M
通讯作者：
Morita, M
影响因子：
158.5
作者：
DOCKERY, DW;POPE, CA;SPEIZER, FE
通讯作者：
SPEIZER, FE
DOI：
10.1164/ajrccm.155.4.9105082
发表时间：
1997-04-01
影响因子：
24.7
作者：
Peters, A;Wichmann, HE;Heyder, J
通讯作者：
Heyder, J