Impact of targeting insulin-like growth factor signaling in head and neck cancers.
Impact of targeting insulin-like growth factor signaling in head and neck cancers.
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DOI：
10.1016/j.ghir.2013.06.001
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发表时间：
2013-10
影响因子：
1.4
通讯作者：
Fribley, Andrew
中科院分区：
文献类型：
--
作者：
Limesand, Kirsten H.;Chibly, Alejandro Martinez;Fribley, Andrew
IGF系统已被证明对肿瘤发展的临床结果有负面或可忽略不计的影响，这取决于特定的肿瘤部位或分期。本文综述了IGF信号在头颈癌中的临床作用、IGF靶向治疗的效果以及IRS 1/2信号在靶向治疗耐药中的潜在机制中的多维作用。与其他肿瘤部位类似，IGF-1/IGF-1- r水平与头颈癌的临床结局之间存在负相关和正相关的报道。此外，利用IGF靶向治疗尚未显示出显著的临床益处；因此，IGF系统对头颈癌的预后影响仍不确定。
The IGF system has been shown to have either negative or negligible impact on clinical outcomes of tumor development depending on specific tumor sites or stages. This review focuses on the clinical impact of IGF signaling in head and neck cancer, effects of IGF targeted therapies, and the multi-dimensional role of IRS 1/2 signaling as a potential mechanism in resistance to targeted therapies. Similar to other tumor sites, both negative and positive correlations between levels of IGF-1/IGF-1-R and clinical outcomes in head and neck cancer have been reported. In addition, utilization of IGF targeted therapies has not demonstrated significant clinical benefit; therefore the prognostic impact of the IGF system on head and neck cancer remains uncertain.
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影响因子：
3.8
作者：
Jacobs, Elizabeth T.;Martinez, Maria Elena;Thompson, Patricia A.
通讯作者：
Thompson, Patricia A.
DOI：
10.1083/jcb.200403069
发表时间：
2004-07-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Harrington LS;Findlay GM;Gray A;Tolkacheva T;Wigfield S;Rebholz H;Barnett J;Leslie NR;Cheng S;Shepherd PR;Gout I;Downes CP;Lamb RF
通讯作者：
Lamb RF
影响因子：
50.5
作者：
Kindler, H. L.;Richards, D. A.;Fuchs, C. S.
通讯作者：
Fuchs, C. S.
影响因子：
6.2
作者：
Chen, C;Lewis, SK;Weiss, NS
通讯作者：
Weiss, NS
DOI：
10.1016/j.ijrobp.2011.03.030
发表时间：
2011-09-01
影响因子：
7
作者：
Isebaert, Sofie F.;Swinnen, Johannes V.;Haustermans, Karin M.
通讯作者：
Haustermans, Karin M.