Effect of caloric restriction on depression.

Effect of caloric restriction on depression.
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DOI:
10.1111/jcmm.13418
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发表时间:
2018-05
影响因子:
5.3
通讯作者:
Li BJ
Li BJ
中科院分区:
医学2区
文献类型:
--
作者:
Manchishi SM;Cui RJ;Zou XH;Cheng ZQ;Li BJ

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近年来,大量研究表明,在抑郁症动物模型中,热量限制可诱导抗抑郁样作用。基于脑-肠轴的研究,某些信号通路在控制热量限制和抑郁之间是共同的。然而,热量限制诱导的抗抑郁样作用的具体机制仍不清楚。本文就热量限制治疗抑郁症的临床和实验研究进行综述。本综述为抑郁症的治疗提供了新的思路。
Recently, most of evidence shows that caloric restriction could induce antidepressant‐like effects in animal model of depression. Based on studies of the brain–gut axis, some signal pathways were common between the control of caloric restriction and depression. However, the specific mechanism of the antidepressant‐like effects induced by caloric restriction remains unclear. Therefore, in this article, we summarized clinical and experimental studies of caloric restriction on depression. This review may provide a new therapeutic strategy for depression.
生长素释放肽在雌激素缺乏的小鼠中产生抗抑郁样作用
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