Monocyte/macrophages and their role in HIV neuropathogenesis.
Monocyte/macrophages and their role in HIV neuropathogenesis.
复制标题
DOI：
10.1111/imr.12068
复制
发表时间：
2013-07
影响因子：
8.7
通讯作者：
Williams KC
中科院分区：
文献类型：
--
作者：
Burdo TH;Lackner A;Williams KC
Neurologic sequelae of human immunodeficiency virus (HIV) infection have been and remain a significant problem. Monocytes and macrophages in humans and monkeys are susceptible to infection by HIV and simian immunodeficiency virus (SIV) and are considered to be a main mechanism by which the central nervous system (CNS) is infected. Within the infected CNS, perivascular macrophages and, in some cases, parenchymal microglia are infected as are multi-nucleated giant cells (MNGC) when present. While neurons are not themselves directly infected, neuronal damage occurs within the infected CNS. Despite the success of anti-retroviral therapy (ART) in limiting virus in plasma to non-detectable levels, neurological deficits persist. This review discusses the continued neurological dysfunctions that persist in the era of ART, focusing on the roles of monocyte and macrophage as targets of continued viral infection and as agents of pathogenesis in what appears to be emergent macrophage-mediated disease resulting from long-term HIV infection of the host. Data discussed include the biology of monocyte/macrophage activation with HIV and SIV infection, traffic of cells into and out of the CNS with infection, macrophage-associated biomarkers of CNS and cardiac disease, the role of antiretroviral therapy on these cells and CNS disease, as well as the need for effective adjunctive therapies targeting monocytes and macrophages.
登录
查看更多内容
影响因子：
9.9
作者：
Childs, EA;Lyles, RH;McArthur, JC
通讯作者：
McArthur, JC
影响因子：
6
作者：
Borda, Juan T.;Alvarez, Xavier;Lackner, Andrew A.
通讯作者：
Lackner, Andrew A.
影响因子：
11.8
作者：
Armah, Kaku A.;McGinnis, Kathleen;Freiberg, Matthew
通讯作者：
Freiberg, Matthew
影响因子：
11.2
作者：
BRUCK, W;PORADA, P;LASSMANN, H
通讯作者：
LASSMANN, H
影响因子：
3.8
作者：
Cinque, P;Vago, L;Poli, G
通讯作者：
Poli, G