Adding zinc to prenatal iron and folate supplements improves maternal and neonatal zinc status in a Peruvian population.
Adding zinc to prenatal iron and folate supplements improves maternal and neonatal zinc status in a Peruvian population.
复制标题
在产前铁和叶酸补充剂中添加锌可以改善秘鲁人群中孕产妇和新生儿的锌状况。
DOI：
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复制
发表时间：
1999
影响因子：
7.1
通讯作者：
A. Figueroa
中科院分区：
文献类型：
--
作者：
L. Caulfield;N. Zavaleta;A. Figueroa
背景
在发展中国家的妇女中，孕妇在怀孕期间缺锌可能很普遍，但关于产前补锌是否能改善孕妇和新生儿的锌状况的数据很少。
目的
我们在秘鲁的一个棚户区研究了母亲补锌是否能改善母亲和新生儿的锌状况。
设计
从妊娠第10-24周开始，1295名母亲被随机分配接受产前补充剂，其中含有60 mg Fe和250 μ g叶酸，含或不含15 mg Zn。在入组时、妊娠第28-30周和妊娠第37-38周采集静脉血液和尿液样本。出生时，采集脐带静脉血样本。我们测量了538名妇女的血清锌浓度，521名妇女的尿锌浓度和252名新生儿的脐带锌浓度。
结果
在28-30周和37-38周，接受锌补充剂的母亲的血清锌浓度高于未接受锌补充剂的母亲（分别为8.8 +/- 1.9和8.4 +/- 1.5 μ mol/L，8.6 +/- 1.5和8.3 +/- 1.4 μ mol/L）。补充锌的母亲尿锌浓度也较高（P < 0.05）。校正协变量和混杂因素后，接受锌补充剂的母亲的新生儿的脐带锌浓度高于未接受锌补充剂的母亲的新生儿（12.7 +/- 2.3与12.1 +/- 2.1 μ mol/L）。尽管补充，产妇和新生儿锌浓度仍然低于营养良好的人口报告的值。
结论
在产前铁和叶酸片中添加锌可以改善产妇和新生儿的锌状况，但可能需要更高剂量的锌来进一步改善这一人群的产妇和新生儿的锌状况。
BACKGROUND
Maternal zinc deficiency during pregnancy may be widespread among women in developing countries, but few data are available on whether prenatal zinc supplementation improves maternal and neonatal zinc status.
OBJECTIVE
We studied whether maternal zinc supplementation improved the zinc status of mothers and neonates participating in a supplementation trial in a shantytown in Lima, Peru.
DESIGN
Beginning at gestation week 10-24, 1295 mothers were randomly assigned to receive prenatal supplements containing 60 mg Fe and 250 microg folate, with or without 15 mg Zn. Venous blood and urine samples were collected at enrollment, at gestation week 28-30, and at gestation week 37-38. At birth, a sample of cord vein blood was collected. We measured serum zinc concentrations in 538 women, urinary zinc concentrations in 521 women, and cord zinc concentrations in 252 neonates.
RESULTS
At 28-30 and 37-38 wk, mothers receiving zinc supplements had higher serum zinc concentrations than mothers who did not receive zinc (8.8 +/- 1.9 compared with 8.4 +/- 1.5 micromol/L and 8.6 +/- 1.5 compared with 8.3 +/- 1.4 micromol/L, respectively). Urinary zinc concentrations were also higher in mothers who received supplemental zinc (P < 0.05). After adjustment for covariates and confounding factors, neonates of mothers receiving zinc supplements had higher cord zinc concentrations than neonates of mothers who did not receive zinc (12.7 +/- 2.3 compared with 12.1 +/- 2.1 micromol/L). Despite supplementation, maternal and neonatal zinc concentrations remained lower than values reported for well-nourished populations.
CONCLUSION
Adding zinc to prenatal iron and folate tablets improved maternal and neonatal zinc status, but higher doses of zinc are likely needed to further improve maternal and neonatal zinc status in this population.
影响因子：
7.1
作者：
NEGGERS, YH;CUTTER, GR;ROSEMAN, JM
通讯作者：
ROSEMAN, JM
DOI：
10.1001/jama.1995.03530060037030
发表时间：
1995-08
期刊：
JAMA
影响因子：
--
作者：
R L Goldenberg;Tsunenobu Tamura;Y. Neggers;R. Copper;K. Johnston;M. Dubard;J. Hauth
通讯作者：
R L Goldenberg;Tsunenobu Tamura;Y. Neggers;R. Copper;K. Johnston;M. Dubard;J. Hauth