Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes.
Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes.
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DOI：
10.1371/journal.pone.0051171
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Hosoya T
中科院分区：
文献类型：
--
作者：
Yokoyama K;Nakashima A;Urashima M;Suga H;Mimura T;Kimura Y;Kanazawa Y;Yokota T;Sakamoto M;Ishizawa S;Nishimura R;Kurata H;Tanno Y;Tojo K;Kageyama S;Ohkido I;Utsunomiya K;Hosoya T
我们旨在检测2型糖尿病患者血清25-羟基维生素D(25OHD)水平、1，25-二氢维生素D(1，25OHD)水平、维生素D受体(VDR)基因多态性和基于估计的肾小球滤过率(EGFR)的肾功能之间的关系。在一项对410名患者进行的横断面研究中，采用有序Logistic回归模型对410名患者的慢性肾脏病(CKD)分期与25OHD、1，25OHD和VDR FokI(Rs10735810)基因多态性进行了比较，调整了以下混杂因素：病程、日历月、血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂或他汀类药物的使用，以及血清钙、磷和完整的甲状旁腺激素水平。125OHD水平，而不是25OHD水平，显示出季节性振荡；峰值出现在5月至10月，最低水平出现在12月至2月。∼与25OHD和1，25OHD呈正相关(P<；0.0001)，但与1，25OHD(r = 0.73)比25OHD(r = 0.22)有更强的线性关系。多变量分析显示，1，25OHD水平(P<；0.001)与慢性肾脏病分期呈负相关，而与25OHD水平无关。尽管FokI基因多态性本身与慢性肾脏病分期无显著关联，但1，25OHD与FokITT之间存在显著的交互作用(P = 0.008)。FokICT和CC基因多态与1，25OHD和EGFR的正相关性(r = 为0.74)明显高于FokITT基因多态(r = 为0.65)。这些结果表明，较高的1，25OHD水平可能与2型糖尿病患者较好的CKD分期有关，这种关联被FokI基因多态改变。
We aimed to examine associations among serum 25-hydroxyvitamin D (25OHD) levels, 1,25-dihyroxyvitamin D (1,25OHD) levels, vitamin D receptor (VDR) polymorphisms, and renal function based on estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes. In a cross-sectional study of 410 patients, chronic kidney disease (CKD) stage assessed by eGFR was compared with 25OHD, 1,25OHD, and VDR FokI (rs10735810) polymorphisms by an ordered logistic regression model adjusted for the following confounders: disease duration, calendar month, use of angiotensin converting enzyme inhibitors/angiotensin receptor blockers or statins, and serum calcium, phosphate, and intact parathyroid hormone levels. 1,25OHD levels, rather than 25OHD levels, showed seasonal oscillations; peak levels were seen from May to October and the lowest levels were seen from December to February. These findings were evident in patients with CKD stage 3∼5 but not stage 1∼2. eGFR was in direct proportion to both 25OHD and 1,25OHD levels (P<0.0001), but it had stronger linearity with 1,25OHD (r = 0.73) than 25OHD (r = 0.22) levels. Using multivariate analysis, 1,25OHD levels (P<0.001), but not 25OHD levels, were negatively associated with CKD stage. Although FokI polymorphisms by themselves showed no significant associations with CKD stage, a significant interaction between 1,25OHD and FokITT was observed (P = 0.008). The positive association between 1,25OHD and eGFR was steeper in FokICT and CC polymorphisms (r = 0.74) than FokITT polymorphisms (r = 0.65). These results suggest that higher 1,25OHD levels may be associated with better CKD stages in patients with type 2 diabetes and that this association was modified by FokI polymorphisms.
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通讯作者：
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影响因子：
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de Borst, Martin H.;Vervloet, Marc G.;Navis, Gerjan
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