The central amygdala as an integrative hub for anxiety and alcohol use disorders.
The central amygdala as an integrative hub for anxiety and alcohol use disorders.
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DOI：
10.1016/j.biopsych.2014.09.008
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发表时间：
2015-05-15
影响因子：
10.6
通讯作者：
Roberto M
中科院分区：
文献类型：
--
作者：
Gilpin NW;Herman MA;Roberto M
中央杏仁核(CEA)在对恐惧刺激、应激刺激和药物相关刺激的生理和行为反应中起着重要作用。CEA接受来自皮质区域的密集输入，是杏仁核的主要输出区，主要是GABA能(抑制性)，并表达高水平的促应激肽和抗应激肽。CEA也是一个概念性宏观结构的组成区域，称为扩展的杏仁核，它是在酒精依赖的过渡过程中招募的。在这篇综述中，我们讨论了CEA中的神经传递作为焦虑症和酒精使用障碍(AUD)之间潜在的整合枢纽，这两种疾病通常在人类中共同发生。人类的成像研究和动物的多学科研究共同表明，患有焦虑症和AUD的人的CEA结构和功能会发生变化，其最终结果可能是调节焦虑和酒精相关行为的下游“效应器”区域的解除抑制。
The central amygdala (CeA) plays a central role in physiological and behavioral responses to fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from cortical regions, is the major output region of the amygdala, is primarily GABAergic (inhibitory), and expresses high levels of pro- and anti-stress peptides. The CeA is also a constituent region of a conceptual macrostructure called the extended amygdala that is recruited during the transition to alcohol dependence. In this review, we discuss neurotransmission in the CeA as a potential integrative hub between anxiety disorders and Alcohol Use Disorder (AUD), which are commonly co-occurring in humans. Human imaging work and multi-disciplinary work in animals collectively suggest that CeA structure and function are altered in individuals with anxiety disorders and AUD, the end result of which may be disinhibition of downstream “effector” regions that regulate anxiety- and alcohol-related behaviors.
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影响因子：
4.3
作者：
Cruz MT;Bajo M;Maragnoli ME;Tabakoff B;Siggins GR;Roberto M
通讯作者：
Roberto M
DOI：
10.1097/01.alc.0000158940.05529.0a
发表时间：
2005-04-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Adinoff, B;Krebaum, SR;Williams, MJ
通讯作者：
Williams, MJ
影响因子：
5.3
作者：
Ciccocioppo, Roberto;de Guglielmo, Giordano;Roberto, Marisa
通讯作者：
Roberto, Marisa
影响因子：
--
作者：
Baklavadzhyan, O G;Pogosyan, N L;Nikogosyan, T G
通讯作者：
Nikogosyan, T G
DOI：
10.1073/pnas.0802302105
发表时间：
2008-06-17
影响因子：
11.1
作者：
Bajo, Michal;Cruz, Maureen T.;Roberto, Marisa
通讯作者：
Roberto, Marisa