Microenvironmental Factors that Shape Bacterial Metabolites in Inflammatory Bowel Disease.
Microenvironmental Factors that Shape Bacterial Metabolites in Inflammatory Bowel Disease.
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DOI：
10.3389/fcimb.2022.934619
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症性肠病（IBD）是一个重要的全球性健康问题，涉及慢性肠道炎症，并可能涉及严重的合并症，包括肠纤维化和炎症相关结直肠癌（CRC）。肠道微生物群的疾病相关改变通常包括肠杆菌科的粪便富集，这与IBD的发展密切相关。这种肠道菌群失调伴随着微生物代谢物的变化，塑造宿主：微生物相互作用和疾病风险。虽然已经有许多研究将特定的细菌分类群与IBD的发展联系起来，但我们对IBD背景下微生物功能的理解有限。几种类型的微生物代谢物与IBD疾病进展有直接关系，包括细菌铁载体和基因毒素。然而，我们的微生物群中仍然含有数千种未被识别的微生物产物。深入发现和表征疾病相关的微生物代谢物是IBD治疗策略中针对这些产品的必要条件。为了提高我们对IBD中微生物群代谢物的理解，认识宿主相关因素如何影响微生物群功能是很重要的。例如，宿主炎症状态、金属有效性、菌间群落结构和外源物的变化都在塑造肠道微生物生态中发挥重要作用。在这篇综述中，我们概述了这些因素如何影响肠道微生物功能，特别关注与ibd相关的肠杆菌科代谢物。重要的是，我们讨论了改变肠道微环境如何改善肠道炎症和相关疾病的治疗，如肠纤维化和CRC。
Inflammatory bowel disease (IBD) is a significant global health problem that involves chronic intestinal inflammation and can involve severe comorbidities, including intestinal fibrosis and inflammation-associated colorectal cancer (CRC). Disease-associated alterations to the intestinal microbiota often include fecal enrichment of Enterobacteriaceae, which are strongly implicated in IBD development. This dysbiosis of intestinal flora accompanies changes in microbial metabolites, shaping host:microbe interactions and disease risk. While there have been numerous studies linking specific bacterial taxa with IBD development, our understanding of microbial function in the context of IBD is limited. Several classes of microbial metabolites have been directly implicated in IBD disease progression, including bacterial siderophores and genotoxins. Yet, our microbiota still harbors thousands of uncharacterized microbial products. In-depth discovery and characterization of disease-associated microbial metabolites is necessary to target these products in IBD treatment strategies. Towards improving our understanding of microbiota metabolites in IBD, it is important to recognize how host relevant factors influence microbiota function. For example, changes in host inflammation status, metal availability, interbacterial community structure, and xenobiotics all play an important role in shaping gut microbial ecology. In this minireview, we outline how each of these factors influences gut microbial function, with a specific focus on IBD-associated Enterobacteriaceae metabolites. Importantly, we discuss how altering the intestinal microenvironment could improve the treatment of intestinal inflammation and associated disorders, like intestinal fibrosis and CRC.
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影响因子：
16.6
作者：
Arthur, Janelle C.;Gharaibeh, Raad Z.;Muehlbauer, Marcus;Perez-Chanona, Ernesto;Uronis, Joshua M.;McCafferty, Jonathan;Fodor, Anthony A.;Jobin, Christian
通讯作者：
Jobin, Christian
影响因子：
14.8
作者：
Chaturvedi, Kaveri S.;Hung, Chia S.;Crowley, Jan R.;Stapleton, Ann E.;Henderson, Jeffrey P.
通讯作者：
Henderson, Jeffrey P.
影响因子：
2.1
作者：
Bach, S;de Almeida, A;Carniel, E
通讯作者：
Carniel, E
影响因子：
5.7
作者：
Diaz-Ochoa VE;Jellbauer S;Klaus S;Raffatellu M
通讯作者：
Raffatellu M
影响因子：
5.6
作者：
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通讯作者：
Ji G