Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys.
Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys.
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DOI：
10.1016/j.freeradbiomed.2021.03.003
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发表时间：
2021-05-01
影响因子：
7.4
通讯作者：
Elsworth JD
中科院分区：
文献类型：
--
作者：
Jamwal S;Blackburn JK;Elsworth JD
一些神经退行性疾病的发展，如帕金森氏病，与线粒体性能下降有关，导致氧化应激，原因是活性氧物种(ROS)的产生增加。以往的研究已经证实，线粒体酶对氧磷酶-2(PON2)具有强大的抗氧化和抗炎特性，其表达与较低的ROS水平有关。本研究的目的是探索非洲绿猴不同脑区(纹状体、海马体、枕叶皮质和背外侧前额叶皮质)PON2蛋白水平的性别差异。我们的结果显示，在每个被检查的脑区中，女性PON2的表达都显著高于男性。由于帕金森氏症在男性中比女性更常见，并且以黑质纹状体系统中的氧化应激为特征，这些发现增加了越来越多的证据，证明PON2是抗击这种疾病的治疗方法的开发目标。
The development of several neurodegenerative disorders, such as Parkinson’s disease, has been linked with decreased mitochondrial performance, leading to oxidative stress as a result of increased production of reactive oxygen species (ROS). Previous studies have established that the mitochondrial enzyme, paraoxonase-2 (PON2), possesses potent antioxidant and anti-inflammatory properties, with its expression linked with lower ROS levels. The aim of this study was to explore the sex-based variations in the protein level of PON2 in different brain regions (striatum, hippocampus, occipital cortex, and dorsolateral prefrontal cortex) of African green monkeys. Our results revealed that the PON2 expression in females was significantly higher than in males, in each of the examined brain regions. As Parkinson’s disease is more prevalent in males compared with females and is characterized by oxidative stress in the nigrostriatal system, these findings add to the growing evidence for PON2 as a target for development of therapeutics to combat this disorder.
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影响因子：
4.8
作者：
Gaignard P;Liere P;Thérond P;Schumacher M;Slama A;Guennoun R
通讯作者：
Guennoun R
影响因子：
5.3
作者：
Blackburn, Jennifer K.;Curry, Daniel W.;Elsworth, John D.
通讯作者：
Elsworth, John D.
影响因子：
3.4
作者：
Costa, Lucio G.;de Laat, Rian;Furlong, Clement E.
通讯作者：
Furlong, Clement E.
影响因子：
5.1
作者：
Garrick, Jacqueline M.;Dao, Khoi;Costa, Lucio G.
通讯作者：
Costa, Lucio G.
影响因子：
3.8
作者：
Prokai, L;Prokai-Tatrai, K;Simpkins, JW
通讯作者：
Simpkins, JW