Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord.
Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord.
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与你的感官接触：脊髓背侧感觉中间神经元的机制。
DOI：
10.1002/wsbm.1520
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发表时间：
2021-09
影响因子：
3.1
通讯作者：
Butler SJ
中科院分区：
文献类型：
--
作者：
Gupta S;Butler SJ
脊髓在功能和解剖学上分为腹侧衍生的运动回路和背侧衍生的躯体感觉回路。源自身体外周或内部的感觉刺激被传递到脊髓背侧，在那里由不同类别的感觉性背侧中间神经元（dIs）进行处理。dIs将诸如疼痛、热或痒等感觉信息传递到大脑和/或运动回路以引发适当的反应。它们还调节感觉信息的强度，并且是阿片类镇痛药的主要靶点。虽然指导腹侧和背侧细胞命运的发育机制被假定是相似的，但最近的研究表明，dI命运是由新的机制决定的。在这篇综述中，我们将讨论决定脊髓背侧神经元模式形成的分子事件，从而产生多样的dI特性。然后我们将讨论这种对分子的理解如何促使强大的干细胞方法的发展，以获得多种脊髓细胞类型，包括dIs，以及这些研究对治疗脊髓损伤和神经退行性疾病的意义。
神经疾病>干细胞与发育
本文分类如下：
生成不同群体的干细胞衍生的脊髓感觉中间神经元的发育导向策略
The spinal cord is functionally and anatomically divided into ventrally derived motor circuits and dorsally derived somatosensory circuits. Sensory stimuli originating either at the periphery of the body, or internally, are relayed to the dorsal spinal cord where they are processed by distinct classes of sensory dorsal interneurons (dIs). dIs convey sensory information, such as pain, heat or itch, either to the brain, and/or to the motor circuits to initiate the appropriate response. They also regulate the intensity of sensory information and are the major target for the opioid analgesics. While the developmental mechanisms directing ventral and dorsal cell fates have been hypothesized to be similar, more recent research has suggested that dI fates are specified by novel mechanisms. In this review, we will discuss the molecular events that specify dorsal neuronal patterning in the spinal cord, thereby generating diverse dI identities. We will then discuss how this molecular understanding has led to the development of robust stem cell methods to derive multiple spinal cell types, including the dIs, and the implication of these studies for treating spinal cord injuries and neurodegenerative diseases. Neurological Diseases > Stem Cells and Development This article is categorized under: Developmentally guided strategies to generate different populations of stem‐cell derived spinal sensory interneurons
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DOI：
10.1126/science.aac8653
发表时间：
2015-10-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bourane S;Duan B;Koch SC;Dalet A;Britz O;Garcia-Campmany L;Kim E;Cheng L;Ghosh A;Ma Q;Goulding M
通讯作者：
Goulding M
影响因子：
2.7
作者：
Asahina, Kinji;Teramoto, Kenichi;Teraoka, Hirobumi
通讯作者：
Teraoka, Hirobumi
影响因子：
9.2
作者：
Brown, JM;Storey, KG
通讯作者：
Storey, KG
影响因子：
64.8
作者：
Andersson, Lisa S.;Larhammar, Martin;Memic, Fatima;Wootz, Hanna;Schwochow, Doreen;Rubin, Carl-Johan;Patra, Kalicharan;Arnason, Thorvaldur;Wellbring, Lisbeth;Hjalm, Goran;Imsland, Freyja;Petersen, Jessica L.;McCue, Molly E.;Mickelson, James R.;Cothran, Gus;Ahituv, Nadav;Roepstorff, Lars;Mikko, Sofia;Vallstedt, Anna;Lindgren, Gabriella;Andersson, Leif;Kullander, Klas
通讯作者：
Kullander, Klas
影响因子：
7.7
作者：
Andrews, Madeline G.;del Castillo, Lorenzo M.;Butler, Samantha J.
通讯作者：
Butler, Samantha J.