Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.
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DOI：
10.1038/nature11399
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发表时间：
2012-08-30
期刊：
影响因子：
64.8
通讯作者：
Kullander, Klas
中科院分区：
文献类型：
--
作者：
Andersson, Lisa S.;Larhammar, Martin;Memic, Fatima;Wootz, Hanna;Schwochow, Doreen;Rubin, Carl-Johan;Patra, Kalicharan;Arnason, Thorvaldur;Wellbring, Lisbeth;Hjalm, Goran;Imsland, Freyja;Petersen, Jessica L.;McCue, Molly E.;Mickelson, James R.;Cothran, Gus;Ahituv, Nadav;Roepstorff, Lars;Mikko, Sofia;Vallstedt, Anna;Lindgren, Gabriella;Andersson, Leif;Kullander, Klas
哺乳动物的运动依赖于在发育过程中建立的协调肢体运动的脊髓中间神经元的中央模式生成电路。这些网络产生肢体的左右交替以及屈肌和伸肌的协调激活。在这里，我们表明，在DMRT3基因的提前终止密码子有一个主要的影响，在马的运动模式。突变是允许的能力，执行交替步态，并有一个有利的影响，利用赛车性能。对野生型和Dmrt3缺失小鼠的研究表明，Dmrt3在脊髓神经元的dI6亚群中表达，参与该亚群中的神经元特化，并且对于控制肢体运动的协调运动网络的正常发育至关重要。我们的发现将Dmrt3定位在配置脊椎动物中控制步幅的脊髓回路的关键作用中。DMRT3突变对国内马的多样化产生了重大影响，因为许多品种的步态特征改变显然需要这种突变。
Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement. These networks produce left–right alternation of limbs as well as coordinated activation of flexor and extensor muscles. Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses. The mutation is permissive for the ability to perform alternate gaits and has a favourable effect on harness racing performance. Examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated locomotor network controlling limb movements. Our discovery positions Dmrt3 in a pivotal role for configuring the spinal circuits controlling stride in vertebrates. The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation.
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影响因子：
2.6
作者：
JOSTES, B;WALTHER, C;GRUSS, P
通讯作者：
GRUSS, P
影响因子：
56.9
作者：
Kullander, K;Butt, SJB;Kiehn, O
通讯作者：
Kiehn, O
DOI：
10.1111/j.1749-6632.2010.05437.x
发表时间：
2010-01-01
期刊：
NEURONS AND NETWORKS IN THE SPINAL CORD
影响因子：
--
作者：
Gallarda, Benjamin W.;Sharpee, Tatyana O.;Alaynick, William A.
通讯作者：
Alaynick, William A.
影响因子：
5.5
作者：
Jankowska, E;Edgley, SA;Hammar, I
通讯作者：
Hammar, I
影响因子：
9.8
作者：
Ahituv N;Zhu Y;Visel A;Holt A;Afzal V;Pennacchio LA;Rubin EM
通讯作者：
Rubin EM