Obesity and angiolymphatic invasion in primary breast cancer.
Obesity and angiolymphatic invasion in primary breast cancer.
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DOI：
10.1245/s10434-009-0797-6
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发表时间：
2010-03
影响因子：
3.7
通讯作者：
Griggs JJ
中科院分区：
文献类型：
--
作者：
Gillespie EF;Sorbero ME;Hanauer DA;Sabel MS;Herrmann EJ;Weiser LJ;Jagielski CH;Griggs JJ
肥胖与较差的乳腺癌特异性生存率相关。本研究的目的是调查肥胖与血管淋巴侵犯以及浸润性乳腺癌其他特征之间的关系，包括就诊时的分期、雌激素受体 (ER) 状态、三阴性表型和肿瘤分级。详细的临床和病理数据从 2000 年 1 月 1 日至 2006 年 12 月 31 日期间在密歇根大学综合癌症中心接受乳腺手术的所有 1,312 名 I – III 期原发性乳腺癌患者的病历中提取。通过双变量和多变量分析来研究体重指数与控制绝经状态、糖尿病和高血压、激素替代的肿瘤生物学特征之间的关系。 诊断前的治疗、种族和民族。在多变量分析中，严重肥胖与血管淋巴侵犯的存在独立相关（比值比，OR 1.80，95% C.I. 1.08 至 2.99，联合显着性检验，p = 0.03）。严重肥胖与三阴性乳腺癌的可能性较低相关（OR 0.39，95% C.I. 0.16 至 0.96）。在患有糖尿病的绝经前女性中，ER阴性（OR 5.22，95% C.I. 1.22至24.29）和三阴性（OR 14.8，95% C.I. 1.92至113.91）疾病明显更常见。在这个浸润性乳腺癌的大样本中，肥胖与血管淋巴侵袭的存在独立相关。肥胖女性血管淋巴侵袭率较高可能是肥胖女性乳腺癌预后较差的部分原因。
Obesity is associated with poorer breast cancer-specific survival. The purpose of this study was to investigate the relationships between obesity and the presence of angiolymphatic invasion as well as other features of invasive breast cancer, including stage at presentation, estrogen receptor (ER) status, the triple-negative phenotype, and tumor grade. Detailed clinical and pathologic data were abstracted from the medical records of all 1,312 patients with Stage I – III primary breast cancer who had breast surgery at the University of Michigan Comprehensive Cancer Center between January 1, 2000 and December 31, 2006. Bivariate and multivariate analyses were conducted to investigate the relationships between body mass index and tumor biologic features controlling for menopausal status, diabetes and hypertension, hormone replacement therapy before diagnosis, race, and ethnicity. In multivariate analyses, severe obesity was independently associated with the presence of angiolymphatic invasion (odds ratio, OR 1.80, 95% C.I. 1.08 to 2.99, joint test of significance, p = 0.03). Severe obesity was associated with a lower likelihood of triple-negative breast cancer (OR 0.39, 95% C.I. 0.16 to 0.96). Among premenopausal women with diabetes, ER-negative (OR 5.22, 95% C.I. 1.22 to 24.29) and triple-negative (OR 14.8, 95% C.I. 1.92 to 113.91) disease was significantly more common. In this large sample of invasive breast cancers, obesity was independently associated with the presence of angiolymphatic invasion. Higher rates of angiolymphatic invasion among obese women may account in part for the poorer outcomes among obese women with breast cancer.
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影响因子：
6.4
作者：
Dal Maso, Luigino;Zucchetto, Antonella;Franceschi, Silvia
通讯作者：
Franceschi, Silvia
影响因子：
3.8
作者：
Loi, S;Milne, RL;Phillips, KA
通讯作者：
Phillips, KA
影响因子：
6.4
作者：
Braithwaite, Dejana;Tammemagi, C. Martin;Esserman, Laura
通讯作者：
Esserman, Laura
影响因子：
45.3
作者：
Goodwin, PJ;Ennis, M;Hood, N
通讯作者：
Hood, N
影响因子：
3.8
作者：
Abrahamson, Page E.;Gammon, Marilie D.;Coates, Ralph J.
通讯作者：
Coates, Ralph J.