Associations of Childhood and Adulthood Cognition with Bone Mineral Density in Later Adulthood: A Population-Based Longitudinal Study.
Associations of Childhood and Adulthood Cognition with Bone Mineral Density in Later Adulthood: A Population-Based Longitudinal Study.
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DOI：
10.3389/fnagi.2017.00241
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发表时间：
2017
影响因子：
4.8
通讯作者：
Richards M
中科院分区：
文献类型：
--
作者：
Bendayan R;Kuh D;Cooper R;Muthuri S;Muniz-Terrera G;Adams J;Ward K;Richards M
本研究探讨了儿童期和中年期认知能力与老年早期骨骼健康结果之间的关系;以及MRC全国健康与发展调查（NSHD）中这些骨骼指标与同期和随后的认知能力之间的关系。这项英国出生队列研究评估了866名女性和792名男性在60-64岁时的面积和体积骨矿物质密度（aBMD和vBMD），这些骨矿物质密度来自外周定量计算机断层扫描和双能X射线吸收测定法，以及从儿童期到69岁的认知能力。15岁时的认知表现通过语言和非语言能力以及数学测试进行评估;在53岁、60-64岁和69岁时进行记忆和搜索速度任务。协变量包括体型、青春期时间、吸烟、休闲时间体力活动、社会经济环境和绝经时间。多元线性回归分析显示，儿童期认知能力越高，女性髋部aBMD越高，男性皮质和骨小梁vBMD越高。对于女性，髋关节aBMD和总vBMD之间存在正相关，同时认知能力与总vBMD的后续认知能力也存在相关性。对于男性，在60-64岁和69岁时出现了与骨小梁和总vBMD的一些关联，但仅在调整教育，职业类别和健康行为之后。我们的研究结果强调，儿童时期较高的认知能力与老年早期的BMD相关，这些相关性可能通过社会和行为途径来解释。结果表明，在生命早期具有更强认知能力的个体更有可能从事健康的行为（例如，休闲时间体力活动），这反过来又与以后生活中更大的BMD相关。骨骼健康和认知能力之间的关联应在生命过程框架内考虑;在建议未来骨质疏松症和骨折高风险的成年人时，应考虑吸烟和体育活动的潜在作用。
This study explores the association between cognitive ability in childhood and midlife and bone health outcomes in early old age; and the relationships of these bone measures with contemporaneous and subsequent cognitive ability in the MRC National Survey of Health and Development (NSHD). This British birth cohort assessed areal and volumetric bone mineral density (aBMD and vBMD) at age 60–64, derived from peripheral quantitative computed tomography and dual-energy X-ray absorptiometry, and cognitive performance from childhood to age 69, among 866 women and 792 men. Cognitive performance at age 15 was assessed using tests of verbal and non-verbal ability, and mathematics; and memory and search speed tasks were administered at ages 53, 60–64, and 69. Covariates included body size, pubertal timing, smoking, leisure time physical activity, socioeconomic circumstances and menopause timing. Multiple linear regression analyses showed that higher childhood cognitive ability was associated with higher hip aBMD, in women, and greater cortical and trabecular vBMD, in men. For women, there were positive associations between hip aBMD and total vBMD, and contemporaneous cognitive ability with associations also extending to subsequent cognitive ability for total vBMD. For men, some associations with trabecular and total vBMD emerged at ages 60–64 and 69 but only after adjusting for education, occupational class and health behaviors. Our findings highlight that higher cognitive ability in childhood is associated with BMD in early old age and these associations might be explained by social and behavioral pathways. The results suggest that individuals with greater cognitive ability in early life are more likely to engage in healthy behaviors (e.g., leisure time physical activity) in adulthood, which in turn are associated with greater BMD later in life. Associations between bone health and cognitive performance should be considered within a life course framework; and the potential role of smoking and physical activity should be addressed when advising adults at high future risk of osteoporosis and fracture.
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DOI：
10.1186/1472-6874-4-2
发表时间：
2004-05-26
期刊：
BMC women's health
影响因子：
--
作者：
Brownbill, Rhonda A;Ilich, Jasminka Z
通讯作者：
Ilich, Jasminka Z
影响因子：
7.7
作者：
Kuh D;Muthuri SG;Moore A;Cole TJ;Adams JE;Cooper C;Hardy R;Ward KA
通讯作者：
Ward KA
影响因子：
6.2
作者：
Berger, Claudie;Goltzman, David;Hanley, David A.
通讯作者：
Hanley, David A.
DOI：
10.1210/jc.2016-1828
发表时间：
2016-10
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Kuh D;Muthuri S;Cooper R;Moore A;Mackinnon K;Cooper C;Adams JE;Hardy R;Ward KA
通讯作者：
Ward KA
影响因子：
7.7
作者：
Cole, T. J.;Kuh, D.;Ong, K. K.
通讯作者：
Ong, K. K.