Physical Properties of Eu(2+)-Containing Cryptates as Contrast Agents for Ultra-High Field Magnetic Resonance Imaging.
Physical Properties of Eu(2+)-Containing Cryptates as Contrast Agents for Ultra-High Field Magnetic Resonance Imaging.
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DOI：
10.1002/ejic.201101166
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发表时间：
2012-04-01
影响因子：
2.3
通讯作者：
Allen, Matthew J.
中科院分区：
文献类型：
--
作者：
Garcia, Joel;Kuda-Wedagedara, Akhila N. W.;Allen, Matthew J.
研究了一系列含Eu2+的隐态化合物的动力学稳定性和弛豫率。在Ca2+、Mg2+和Zn2+存在的情况下，监测水质子纵向弛豫速率变化的跨金属化研究表明，隐酸盐结构影响稳定性，并且在这些内源性离子存在的情况下，两种被研究的隐酸盐对跨金属化是惰性的。在不同的磁场强度、温度和pH值下测定了这些隐酸盐的功效。研究发现，在超高场强（7和9.4 T）下，隐通道的弛性比临床相关场强（1.4和3 T）更高，但随着温度的升高，隐通道的效率降低。此外，pH值的变化并没有对隐菌的功效产生显著的影响。这些研究奠定了重要性质的基础，这些性质对于开发用于含Eu2+的隐体磁共振成像的有效正对比剂是必要的。
The kinetic stabilities and relaxivities of a series of Eu2+-containing cryptates have been investigated. Transmetallation studies that monitored the change in the longitudinal relaxation rate of water protons in the presence of Ca2+, Mg2+, and Zn2+ demonstrated that cryptate structure influences stability, and two of the cryptates studied were inert to transmetallation in the presence of these endogenous ions. The efficacy of these cryptates was determined at different magnetic field strengths, temperatures, and pH values. Cryptate relaxivity was found to be higher at ultra-high field strengths (7 and 9.4 T) relative to clinically relevant field strengths (1.4 and 3 T), but the efficiency of these cryptates decreased as temperature increased. In addition, variation in pH did not yield significant changes in the efficacy of the cryptates. These studies establish a foundation of important properties that are necessary to develop effective positive contrast agents for magnetic resonance imaging from Eu2+-containing cryptates.
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影响因子：
1.2
作者：
Averill, Derek J.;Garcia, Joel;Allen, Matthew J.
通讯作者：
Allen, Matthew J.
毛细管电泳-电感耦合等离子体发射光谱法测定人血浆中的游离钙和含钙物质
影响因子：
7.4
作者：
Deng, Biyang;Zhu, Pingchuan;Xu, Qiumei
通讯作者：
Xu, Qiumei
影响因子：
4.4
作者：
Kruk, D;Kowalewski, J
通讯作者：
Kowalewski, J
DOI：
10.1006/jmra.1996.0149
发表时间：
1996-08-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES A
影响因子：
--
作者：
Svoboda, J;Nilsson, T;Larsson, PT
通讯作者：
Larsson, PT
影响因子：
2.9
作者：
WOLFSON, JM;KEARNS, DR
通讯作者：
KEARNS, DR