Making the LINC: SUN and KASH protein interactions.
Making the LINC: SUN and KASH protein interactions.
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DOI:
10.1515/hsz-2014-0267
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发表时间:
2015-04
影响因子:
3.7
通讯作者:
Roux KJ
中科院分区:
文献类型:
--
作者:
Kim DI;Birendra KC;Roux KJ
Cell nuclei are physically integrated with the cytoskeleton through the LINC complex (for LInker of Nucleoskeleton and Cytoskeleton), a structure that spans the nuclear envelope to link the nucleoskeleton and cytoskeleton. Outer nuclear membrane KASH domain proteins and inner nuclear membrane SUN domain proteins interact to form the core of the LINC complex. In this review we provide a comprehensive analysis of the reported protein-protein interactions for KASH and SUN domain proteins. This critical structure, directly connecting the genome with the rest of the cell, contributes to a myriad of cellular functions and, when perturbed, is associated with human disease.
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