Making the LINC: SUN and KASH protein interactions.

Making the LINC: SUN and KASH protein interactions.
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DOI:
10.1515/hsz-2014-0267
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发表时间:
2015-04
影响因子:
3.7
通讯作者:
Roux KJ
Roux KJ
中科院分区:
生物学2区
文献类型:
--
作者:
Kim DI;Birendra KC;Roux KJ

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细胞核通过LINC复合物(核骨架和细胞骨架的连接物)与细胞骨架物理结合,这种结构跨越核膜连接核骨架和细胞骨架。外核膜KASH结构域蛋白和内核膜SUN结构域蛋白相互作用形成LINC复合物的核心。在这篇综述中,我们提供了报道的KASH和SUN结构域蛋白的蛋白质相互作用的综合分析。这种直接将基因组与细胞其余部分连接起来的关键结构,对无数细胞功能有贡献,当受到干扰时,与人类疾病有关。
Cell nuclei are physically integrated with the cytoskeleton through the LINC complex (for LInker of Nucleoskeleton and Cytoskeleton), a structure that spans the nuclear envelope to link the nucleoskeleton and cytoskeleton. Outer nuclear membrane KASH domain proteins and inner nuclear membrane SUN domain proteins interact to form the core of the LINC complex. In this review we provide a comprehensive analysis of the reported protein-protein interactions for KASH and SUN domain proteins. This critical structure, directly connecting the genome with the rest of the cell, contributes to a myriad of cellular functions and, when perturbed, is associated with human disease.
整联蛋白α6BETA4与原蛋白的结合可预防与F-肌动蛋白的蛋白质结合,但不会干扰中间丝结合。
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