Nonhuman primate models of social behavior and cocaine abuse.
Nonhuman primate models of social behavior and cocaine abuse.
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DOI：
10.1007/s00213-012-2843-5
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发表时间：
2012-11
影响因子：
3.4
通讯作者：
Morgan D
中科院分区：
文献类型：
--
作者：
Nader MA;Czoty PW;Nader SH;Morgan D
虽然可卡因经常在社交场合被滥用，但很少有动物研究在社交行为的背景下研究可卡因的影响。这篇综述强调了研究可卡因的行为影响的背景下，社会住房条件下使用非人灵长类动物。此外，本文还介绍了最近的研究结果，研究自我管理的可卡因对社会行为的影响和操纵的影响假设是紧张或丰富的可卡因强化和社会地位之间的相互作用。检查以下因变量：1）可卡因诱导的社会行为变化和2）不同社会等级的食蟹猴中可卡因自我给药。检查的自变量包括几个环境和药理学操作。这里回顾的研究表明，几个变量可以差异影响可卡因自我管理时，在社会背景下，而不是在单独圈养的动物。这些变量包括个人的社会地位和性别、吸毒史、“恐惧”诱导操纵的性质，以及皮质醇作为“压力”的适当衡量标准的可靠性。虽然纳入社会圈养的动物需要更大的样本量，但纳入社会行为的动物模型与人类状况更相似，应尽可能实施。
Although cocaine is often abused in social situations, very few animal studies examine the effects of cocaine in the context of social behavior. This review highlights studies investigating the behavioral effects of cocaine in the context of social housing conditions using nonhuman primates. In addition, this review presents recent findings examining the effects of self-administering cocaine on social behavior and the effects of manipulations hypothesized to be stressful or enriching on the interactions between cocaine reinforcement and social rank. The following dependent variables are examined: 1) cocaine-induced changes in social behavior and 2) cocaine self-administration in cynomolgus monkeys of varying social ranks. The independent variables examined include several environmental and pharmacological manipulations. The studies reviewed here indicate that several variables can differentially affect cocaine self-administration when studied in a social context, rather than in individually housed animals. These variables include the social rank and sex of the individual, drug history, the nature of the “fear”-inducing manipulation, and the reliability of cortisol as an appropriate measure of “stress.” While the inclusion of socially housed animals necessitates larger sample sizes, animal models incorporating social behavior are more homologous to the human condition and should be implemented when possible.
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影响因子：
2.3
作者：
BARRETT, JE;GLOWA, JR
通讯作者：
GLOWA, JR
影响因子：
1.6
作者：
DRAPER, WA;BERNSTEIN, IS
通讯作者：
BERNSTEIN, IS
影响因子：
3.3
作者：
Amick, BC;McDonough, P;Duncan, G
通讯作者：
Duncan, G
影响因子：
5.3
作者：
Bradberry, CW
通讯作者：
Bradberry, CW
影响因子：
4.2
作者：
Back, Sudie E.;Hartwell, Karen;Braly, Kathleen T.
通讯作者：
Braly, Kathleen T.