Recent advances in 3D bioprinting of musculoskeletal tissues.
Recent advances in 3D bioprinting of musculoskeletal tissues.
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DOI：
10.1088/1758-5090/abc8de
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发表时间：
2021-03-10
期刊：
影响因子：
9
通讯作者：
Ashammakhi N
中科院分区：
文献类型：
--
作者：
Potyondy T;Uquillas JA;Tebon PJ;Byambaa B;Hasan A;Tavafoghi M;Mary H;Aninwene GE 2nd;Pountos I;Khademhosseini A;Ashammakhi N
肌肉骨骼系统对维持姿势、保护器官、促进运动、调节各种细胞和代谢功能至关重要。由于外伤或磨损对该系统的损伤是常见的，严重的损伤可能需要手术来恢复功能并防止进一步的伤害。自体移植物是目前替代丢失或受损组织的金标准。然而，这些移植物受到供应有限和供区发病率的限制。同种异体移植物、异种移植物和同种异体材料都是可行的替代方法，但每种方法都有自己的问题和局限性。三维（3D）打印技术的进步及其生物医学适应性，3D生物打印，有可能提供可行的，自体组织样结构，可用于修复肌肉骨骼缺陷。虽然生物打印目前还无法培育成熟的可植入组织，但它可以在3D结构中塑造细胞，并具有促进成熟和血管形成的特征。该领域的进一步发展可能会使构建物能够在复杂性、空间异质性和最终的临床应用上模仿天然组织。本文综述了3D生物打印在工程骨、软骨、肌肉、肌腱、韧带及其界面组织中的应用。此外，讨论了该领域目前的局限性和挑战，并强调了未来进展的前景。
The musculoskeletal system is essential for maintaining posture, protecting organs, facilitating locomotion, and regulating various cellular and metabolic functions. Injury to this system due to trauma or wear is common, and severe damage may require surgery to restore function and prevent further harm. Autografts are the current gold standard for the replacement of lost or damaged tissues. However, these grafts are constrained by limited supply and donor site morbidity. Allografts, xenografts, and alloplastic materials represent viable alternatives, but each of these methods also has its own problems and limitations. Technological advances in three-dimensional (3D) printing and its biomedical adaptation, 3D bioprinting, have the potential to provide viable, autologous tissue-like constructs that can be used to repair musculoskeletal defects. Though bioprinting is currently unable to develop mature, implantable tissues, it can pattern cells in 3D constructs with features facilitating maturation and vascularization. Further advances in the field may enable the manufacture of constructs that can mimic native tissues in complexity, spatial heterogeneity, and ultimately, clinical utility. This review studies the use of 3D bioprinting for engineering bone, cartilage, muscle, tendon, ligament, and their interface tissues. Additionally, the current limitations and challenges in the field are discussed and the prospects for future progress are highlighted.
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影响因子：
4.7
作者：
Ashammakhi N;Ahadian S;Zengjie F;Suthiwanich K;Lorestani F;Orive G;Ostrovidov S;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
2.9
作者：
CHRISTENSEN, LV
通讯作者：
CHRISTENSEN, LV
影响因子：
14
作者：
Costantini, Marco;Testa, Stefano;Gargioli, Cesare
通讯作者：
Gargioli, Cesare
影响因子：
4
作者：
Boccardi, Elena;Melli, Virginia;De Nardo, Luigi
通讯作者：
De Nardo, Luigi
影响因子：
3.5
作者：
Comiskey, D.;MacDonald, B. J.;O'Byrne, J.
通讯作者：
O'Byrne, J.