A gaze-independent audiovisual brain-computer Interface for detecting awareness of patients with disorders of consciousness.
A gaze-independent audiovisual brain-computer Interface for detecting awareness of patients with disorders of consciousness.
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一种独立于凝视的视听脑机接口，用于检测意识障碍患者的意识
DOI：
10.1186/s12883-018-1144-y
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发表时间：
2018-10-09
期刊：
影响因子：
2.6
通讯作者：
Yu R
中科院分区：
文献类型：
--
作者：
Xie Q;Pan J;Chen Y;He Y;Ni X;Zhang J;Wang F;Li Y;Yu R
目前，检测意识障碍（DOC）患者的意识具有挑战性。脑机接口（BCIs）不依赖于患者的行为反应，可用于检测 DOC 患者的意识。然而，我们必须为这些患者开发有效的脑机接口，因为他们使用脑机接口的能力不如健康用户。由于DOC患者一般不会表现出眼球运动，因此研究中提出了一种与注视无关的视听BCI，其中语义一致和不一致的视听数字刺激依次呈现以唤起事件相关电位（ERP）。要求受试者注意一致的视听刺激（目标）并忽略不一致的视听刺激（非目标）。 BCI 系统通过分析 10 名健康受试者的在线和离线数据进行评估，然后应用于 8 名 DOC 患者的在线意识检测。根据健康受试者的结果，视听 BCI 系统优于相应的纯听觉和纯视觉系统。使用视听系统观察到多个 ERP 组件，包括 P300、N400 和晚期阳性复合物 (LPC)，加强了大脑对目标刺激和非目标刺激的不同反应。结果显示，八名患者中的三名具有遵循命令和识别数字的能力。这种不依赖凝视的视听 BCI 系统是一种有用的辅助床边工具，可检测 DOC 患者的意识。
Currently, it is challenging to detect the awareness of patients who suffer disorders of consciousness (DOC). Brain-computer interfaces (BCIs), which do not depend on the behavioral response of patients, may serve for detecting the awareness in patients with DOC. However, we must develop effective BCIs for these patients because their ability to use BCIs does not as good as healthy users. Because patients with DOC generally do not exhibit eye movements, a gaze-independent audiovisual BCI is put forward in the study where semantically congruent and incongruent audiovisual number stimuli were sequentially presented to evoke event-related potentials (ERPs). Subjects were required to pay attention to congruent audiovisual stimuli (target) and ignore the incongruent audiovisual stimuli (non-target). The BCI system was evaluated by analyzing online and offline data from 10 healthy subjects followed by being applied to online awareness detection in 8 patients with DOC. According to the results on healthy subjects, the audiovisual BCI system outperformed the corresponding auditory-only and visual-only systems. Multiple ERP components, including the P300, N400 and late positive complex (LPC), were observed using the audiovisual system, strengthening different brain responses to target stimuli and non-target stimuli. The results revealed the abilities of three of eight patients to follow commands and recognize numbers. This gaze-independent audiovisual BCI system represents a useful auxiliary bedside tool to detect the awareness of patients with DOC.
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语义丰富性和语义记忆中概念的激活：与事件相关的电位的证据。
影响因子：
2.9
作者：
Kounios J;Green DL;Payne L;Fleck JI;Grondin R;McRae K
通讯作者：
McRae K
DOI：
10.1111/j.1749-6632.2008.04122.x
发表时间：
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期刊：
DISORDERS OF CONSCIOUSNESS
影响因子：
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发表时间：
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作者：
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作者：
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作者：
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