Genotype modulates age-related alterations in sensitivity to the aversive effects of ethanol: an eight inbred strain analysis of conditioned taste aversion.
Genotype modulates age-related alterations in sensitivity to the aversive effects of ethanol: an eight inbred strain analysis of conditioned taste aversion.
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DOI：
10.1111/gbb.12004
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Boehm SL 2nd
中科院分区：
文献类型：
--
作者：
Moore EM;Forrest RD 4th;Boehm SL 2nd
青少年个体对酒精的行为敏感性发生了变化，这可能是这个年龄段酒精消耗量增加的原因之一。然而，基因对酒精摄入量和敏感性也有相当大的影响。到目前为止，很少有研究评估发育和遗传酒精敏感性的联合影响。对8个近交系小鼠(C57BL/6J、DBA/2J、129S1/SvImJ、A/J、BALB/cByJ、BTBR T+Tf/J、C3H/HeJ和FVB/NJ)在青春期(P30)和成年期(P75)用条件性味觉厌恶(CTA)程序测定了对乙醇厌恶效应的敏感性。青春期和成年小鼠缺水，随后给予0.9%(v/v)的氯化钠溶液1h。造模后立即给予乙醇(0，1.5，2.25，3g/kg，ip)。这一过程在总共5次CTA试验中每隔72小时重复一次。对乙醇的厌恶效应的敏感性高度依赖于菌株和年龄。在近亲交配的品系中，青春期的动物对酒精的厌恶作用始终比成年动物更不敏感。然而，产生厌恶反应所需的乙醇剂量随年龄和品系的不同而不同。
Adolescent individuals display altered behavioral sensitivity to ethanol, which may contribute to the increased ethanol consumption seen in this age-group. However, genetics also exert considerable influence on both ethanol intake and sensitivity. Thus far there is little research assessing the combined influence of developmental and genetic alcohol sensitivities. Sensitivity to the aversive effects of ethanol using a conditioned taste aversion (CTA) procedure was measured during both adolescence (P30) and adulthood (P75) in 8 inbred mouse strains (C57BL/6J, DBA/2J, 129S1/SvImJ, A/J, BALB/cByJ, BTBR T+tf/J, C3H/HeJ, and FVB/NJ). Adolescent and adult mice were water deprived, and subsequently provided with access to 0.9% (v/v) NaCl solution for 1h. Immediately following access mice were administered ethanol (0, 1.5, 2.25, 3g/kg, ip). This procedure was repeated in 72h intervals for a total of 5 CTA trials. Sensitivity to the aversive effects of ethanol was highly dependent upon both strain and age. Within an inbred strain, adolescent animals were consistently less sensitive to the aversive effects of ethanol than their adult counterparts. However, the dose of ethanol required to produce an aversion response differed as a function of both age and strain.
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DOI：
10.3758/bf03337315
发表时间：
1993-05-01
期刊：
BULLETIN OF THE PSYCHONOMIC SOCIETY
影响因子：
--
作者：
HOBBS, SH;WALTERS, PA;ELKINS, RL
通讯作者：
ELKINS, RL
影响因子：
2.2
作者：
Revillo, D. A.;Arias, C.;Spear, N. E.
通讯作者：
Spear, N. E.
DOI：
10.1097/00000374-199809000-00008
发表时间：
1998-09-01
影响因子：
3.2
作者：
Risinger, FO;Cunningham, CL
通讯作者：
Cunningham, CL
DOI：
10.1111/j.1530-0277.2011.01528.x
发表时间：
2011-10-01
影响因子：
3.2
作者：
Holstein, Sarah E.;Spanos, Marina;Hodge, Clyde W.
通讯作者：
Hodge, Clyde W.
DOI：
10.1111/j.1530-0277.1998.tb03668.x
发表时间：
1998-04-01
影响因子：
3.2
作者：
Markwiese, BJ;Acheson, SK;Swartzwelder, HS
通讯作者：
Swartzwelder, HS