Precise Topology of Adjacent Domain-General and Sensory-Biased Regions in the Human Brain.

Precise Topology of Adjacent Domain-General and Sensory-Biased Regions in the Human Brain.
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DOI:
10.1093/cercor/bhab362
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发表时间:
2022-06-07
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Cerebral cortex (New York, N.Y. : 1991)
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其他
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最近的功能磁共振成像研究确定了大部分联合皮层和小脑的感觉偏向区域。然而,他们的解剖关系的多需求(MD)的地区,其特点是域一般,由于他们在多个认知需求的共激活,仍然不清楚。为了更好的解剖描绘,我们使用了人类连接组项目的多模态MRI技术来扫描执行视觉和听觉版本的工作记忆(WM)任务的受试者。硬和容易WM之间的对比表现出较强的域的一般性,与基本相同的模式的皮质,皮质下,和小脑MD活动的视觉和听觉材料。相比之下,模态偏好的对比容易WM与基线;大多数MD区域表现出视觉偏好,而紧邻皮层MD区域,有交错的区域的视觉和听觉偏好。这些结果可能揭示了一个一般的基序,即特定领域的区域饲料信息进出一个相邻的,整合的MD核心。
Recent functional MRI studies identified sensory-biased regions across much of the association cortices and cerebellum. However, their anatomical relationship to multiple-demand (MD) regions, characterized as domain-general due to their coactivation during multiple cognitive demands, remains unclear. For a better anatomical delineation, we used multimodal MRI techniques of the Human Connectome Project to scan subjects performing visual and auditory versions of a working memory (WM) task. The contrast between hard and easy WM showed strong domain generality, with essentially identical patterns of cortical, subcortical, and cerebellar MD activity for visual and auditory materials. In contrast, modality preferences were shown by contrasting easy WM with baseline; most MD regions showed visual preference while immediately adjacent to cortical MD regions, there were interleaved regions of both visual and auditory preference. The results may exemplify a general motif whereby domain-specific regions feed information into and out of an adjacent, integrative MD core.
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