Hepatic Stem Cell Compartment: Activation and Lineage Commitment
Hepatic Stem Cell Compartment: Activation and Lineage Commitment
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肝干细胞区室：激活和谱系承诺
DOI：
10.3181/00379727-204-43661
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发表时间：
1993
影响因子：
--
通讯作者：
Zongyi Hu
中科院分区：
文献类型：
--
作者：
S. Thorgeirsson;R. Evarts;H. C. Bisgaard;K. Fujio;Zongyi Hu
越来越多的实验证据支持肝脏中存在多能细胞隔室1，2，3，4，5，6，7。在某些条件下，该隔室可以起到干细胞隔室的作用，并为肝实质的再生提供所需的后代8，9。在成年大鼠中，可以利用特定条件来诱导肝脏导管结构中的小上皮细胞的不同群体的增殖10、11。这些细胞通常被描述为卵圆细胞，其特征在于卵圆核和嗜碱性胞浆10，并显示出胆管细胞和胎儿肝细胞的特征11、12、13。有三个实验系统，两个在大鼠和一个在小鼠中，其中已最终证明，卵圆细胞能够分化成肝细胞8，11，14。然而，卵圆细胞的发育潜力并不局限于肝脏谱系。卵圆细胞可分化为胰腺型上皮细胞，并与胰腺组织的发育有关8，11，15，16，17 ;图1）。观察到增殖卵圆细胞的亚群表型类似于早期成肝细胞，并且卵圆细胞起源于汇管区的导管结构中或周围，强烈支持肝干细胞隔室存在于这些结构中的观点2，7，9。此外，目前的证据清楚地表明，肝干细胞隔室作为兼性干细胞隔室发挥作用，当实质细胞不能响应生长刺激增殖时，该兼性干细胞隔室被激活2，8，18，19。
There is increasingly robust experimental evidence in support of the presence of a pluripotent cell compartment in the liver 1 , 2 , 3 , 4 , 5 , 6 , 7 . This compartment can under certain conditions function as a stem cell compartment and provide the needed progeny for regeneration of the hepatic parenchyma 8 , 9 . In the adult rat, specific conditions can be utilized to induce proliferation of a distinct population of small epithelial cells in the ductal structures of the liver 10 , 11 . These cells, conventionally described as oval cells, are characterized by ovoid nuclei and basophilic cytoplasma 10 , and display features of both bile duct cells and fetal hepatocytes 11 , 12 , 13 . There are three experimental systems, two in the rat and one in the mouse, in which it has been conclusively demonstrated that oval cells are capable of differentiation into hepatocytes 8 , 11 , 14 . The developmental potential of oval cells is, however, not restricted to hepatic lineages. Oval cells can differentiate into intestinal-type epithelia, and have been implicated in the development of pancreatic tissues 8 , 11 , 15 , 16 , 17 ; Fig. 1). The observations that sub-populations of proliferating oval cells phenotypically similar to early hepatoblasts, and that oval cells originate in or around the ductular structures in the portal area, strongly support the notion that the hepatic stem cell compartment resides in these structures 2 , 7 , 9 . Furthermore, present evidence clearly indicates that the hepatic stem cell compartment functions as a facultative stem cell compartment that is activated when the parenchymal cells are unable to proliferate in response to growth stimuli 2 , 8 , 18 , 19 .
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肝脏作为干细胞和谱系系统。
DOI：
10.1152/ajpgi.1992.263.2.g139
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Sigal,SH;Brill,S;Fiorino,AS;Reid,LM
通讯作者：
Reid,LM
影响因子：
4.6
作者：
V. Am;J. Burchette;G. Michalopoulos
通讯作者：
V. Am;J. Burchette;G. Michalopoulos
DOI：
10.1073/pnas.88.24.11310
发表时间：
1991-12-01
影响因子：
11.1
作者：
METCALF, D
通讯作者：
METCALF, D
乙硫氨酸肝癌发生过程中胆管样细胞增殖的组织发生。
DOI：
--
发表时间：
1992
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Lenzi,R;Liu,MH;Tarsetti,F;Slott,PA;Alpini,G;Zhai,WR;Paronetto,F;Lenzen,R;Tavoloni,N
通讯作者：
Tavoloni,N