Prevalence and incidence of hypertension in a heavily treatment-experienced cohort of people living with HIV in Uganda.
Prevalence and incidence of hypertension in a heavily treatment-experienced cohort of people living with HIV in Uganda.
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DOI：
10.1371/journal.pone.0282001
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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作者：
The effect of long-term exposure to antiretroviral therapy (ART) on hypertension in sub-Saharan Africa remains unclear. We aimed to determine the prevalence and incidence of hypertension in people living with HIV (PLWH) with more than 10 years of ART in Uganda. The analysis was performed within a cohort of adult PLWH with more than 10 years of ART at an HIV clinic in Kampala, Uganda. Participants were eligible for this analysis if they had ≥2 follow-up visits. Hypertension was defined as two consecutive systolic blood pressure (SBP) measures greater than 140 mmHg and/or diastolic blood pressure (DBP) greater than 90 mmHg, and/or documented diagnosis and/or the initiation of antihypertensives. We determined the proportion of PLWH with hypertension at baseline and used multivariable logistic regression to determine the factors associated with prevalent hypertension. To determine the incidence of hypertension, follow-up began from the cohort baseline date and was censored at the last clinic visit or date of the event, whichever occurred earlier. Multivariable Poisson regression was used to determine the adjusted incidence rate ratios (aIRR) of hypertension according to demographic, ART, and clinical characteristics. Of the 1000 ALT participants, 970 (97%) had ≥2 follow-up visits, and 237 (24.4%) had hypertension at baseline. The odds of prevalent hypertension were 1.18 for every 5-year increase in age (adjusted odds ratio (aOR) 1.18, 95% CI 1.10–1.34) and were higher among males (aOR 1.70, 95% CI 1.20–2.34), participants with diabetes mellitus (aOR 2.37, 95% CI 1.10–4.01), obesity (aOR 1.99, 95% CI 1.08–3.60), high cholesterol (aOR 1.47, 95% CI 1.16–2.01), and those with prior exposure to stavudine (aOR 2.10, 95% CI 1.35–3.52), or nevirapine (aOR 1.90, 95% CI 1.25–3.01). Of the 733 participants without hypertension at baseline, 116 (15.83%) developed hypertension during 4671.3 person-years of follow-up (incidence rate 24.8 per 1000 person-years; 95% CI 20.7–29.8). The factors associated with incident hypertension were obesity (adjusted incidence rate ratio (aIRR) 1.80, 95% CI 1.40–2.81), older age (aIRR 1.12 per 5-year increase in age, 95% CI 1.10,1.25), and renal insufficiency (aIRR1.80, 95% CI 1.40–2.81). The prevalence and incidence of hypertension were high in this heavily treated PLWH cohort. Therefore, with increasing ART coverage, HIV programs in SSA should strengthen the screening for hypertension in heavily treated PLWH.
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影响因子：
8.1
作者：
Kalyesubula R;Kayongo A;Semitala FC;Muhanguzi A;Katantazi N;Ayers D;Forrest JI;Mills EJ
通讯作者：
Mills EJ
影响因子：
3.7
作者：
Brennan AT;Jamieson L;Crowther NJ;Fox MP;George JA;Berry KM;Stokes A;Maskew M;Sanne I;Long L;Cassim N;Rosen S
通讯作者：
Rosen S
DOI：
10.1111/jch.13092
发表时间：
2017-11
期刊：
Journal of clinical hypertension (Greenwich, Conn.)
影响因子：
--
作者：
Okello S;Ueda P;Kanyesigye M;Byaruhanga E;Kiyimba A;Amanyire G;Kintu A;Fawzi WW;Muyindike WR;Danaei G
通讯作者：
Danaei G
影响因子：
2.2
作者：
Abrahams, Zulfa;Dave, Joel A.;Levitt, Naomi S.
通讯作者：
Levitt, Naomi S.
影响因子：
3
作者：
Hatleberg CI;Ryom L;d'Arminio Monforte A;Fontas E;Reiss P;Kirk O;El-Sadr W;Phillips A;de Wit S;Dabis F;Weber R;Law M;Lundgren JD;Sabin C;Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group
通讯作者：
Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group