Transformation of acoustic information to sensory decision variables in the parietal cortex.
Transformation of acoustic information to sensory decision variables in the parietal cortex.
复制标题
DOI：
10.1073/pnas.2212120120
复制
发表时间：
2023-01-10
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
想象一下，你沿着一条忙碌的街道走着，突然听到身后传来沉重的脚步声。决定是否移动到一边，以避免即将发生的碰撞变得更加明显的每一个额外的脚步声。这一过程需要随着时间的推移整合感官观察，并通过将刺激表征转化为决策变量来实现。我们通过记录顶叶皮层的活动来探索潜在的神经机制，而动物要么执行听觉任务，要么被动地听相同的声音。虽然行为相关的听觉信息表示时，动物被动地听刺激，它只是在任务参与解码顶叶皮层活动直接反映心理测量性能和行为措施的整合时间。感官证据有助于感知选择的过程需要理解其转化为决策变量。在这里，我们解决这个问题，通过评估听觉皮层受体顶叶皮层的声学信息的神经表征，而沙鼠要么进行了两个替代的被迫选择听觉歧视任务，而他们被动地听相同的声学刺激。在任务参与，刺激身份解码性能从同时记录的顶叶神经元显着相关的心理测量敏感性。相比之下，被动收听期间的解码性能显著降低。主成分和几何分析揭示了线性可分流形的低维编码的出现相对于刺激身份和决策，但只有在任务参与。这些研究结果证实，顶叶皮层介导的过渡到决策相关的变量的声学表示。最后，使用聚类分析，我们确定了三个功能不同的神经元亚群，每个编码任务相关的信息在单独的时间段的审判。总之，我们的研究结果表明顶叶皮层神经元如何整合和转换编码的听觉信息，以指导声音驱动的感知决策。
Consider walking along a busy street and suddenly hearing heavy footsteps approaching behind you. Deciding whether to move aside to avoid an impending collision becomes more evident with the sound of each additional footstep. This process requires integrating sensory observations over time and is implemented by transforming stimulus representations into decision variables. We explored the underlying neural mechanisms by recording parietal cortex activity while animals either performed an auditory task or passively listened to the identical sounds. While behaviorally relevant auditory information is represented when animals listen passively to the stimuli, it is only during task engagement that decoded parietal cortex activity directly reflects psychometric performance and behavioral measures of integration time. The process by which sensory evidence contributes to perceptual choices requires an understanding of its transformation into decision variables. Here, we address this issue by evaluating the neural representation of acoustic information in the auditory cortex-recipient parietal cortex, while gerbils either performed a two-alternative forced-choice auditory discrimination task or while they passively listened to identical acoustic stimuli. During task engagement, stimulus identity decoding performance from simultaneously recorded parietal neurons significantly correlated with psychometric sensitivity. In contrast, decoding performance during passive listening was significantly reduced. Principal component and geometric analyses revealed the emergence of low-dimensional encoding of linearly separable manifolds with respect to stimulus identity and decision, but only during task engagement. These findings confirm that the parietal cortex mediates a transition of acoustic representations into decision-related variables. Finally, using a clustering analysis, we identified three functionally distinct subpopulations of neurons that each encoded task-relevant information during separate temporal segments of a trial. Taken together, our findings demonstrate how parietal cortex neurons integrate and transform encoded auditory information to guide sound-driven perceptual decisions.
登录
查看更多内容
影响因子：
5.7
作者：
Brody CD;Hanks TD
通讯作者：
Hanks TD
影响因子：
34.7
作者：
Bizley, Jennifer K.;Cohen, Yale E.
通讯作者：
Cohen, Yale E.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.3
作者：
Hackett TA;de la Mothe LA;Camalier CR;Falchier A;Lakatos P;Kajikawa Y;Schroeder CE
通讯作者：
Schroeder CE
影响因子：
2.5
作者：
Horwitz, GD;Newsome, WT
通讯作者：
Newsome, WT