The most appropriate region-of-interest position for attenuation coefficient measurement in the evaluation of liver steatosis
The most appropriate region-of-interest position for attenuation coefficient measurement in the evaluation of liver steatosis
复制标题
肝脏脂肪变性评估中衰减系数测量最合适的感兴趣区域位置
DOI：
10.1007/s10396-021-01124-z
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发表时间：
2021
影响因子：
1.8
通讯作者：
Itoi Takao
中科院分区：
文献类型：
--
作者：
Sugimoto Katsutoshi;Abe Masakazu;Oshiro Hisashi;Takahashi Hiroshi;Kakegawa Tatsuya;Tomita Yusuke;Yoshimasu Yu;Takeuchi Hirohito;Itoi Takao
衰减成像（ATI）是一种新的无创性超声检查技术，可用于评估脂肪变性程度（S）。然而，有效的感兴趣区域（ROI）采样策略目前还不可用。我们调查了各种ATI-ROI位置的诊断性能，以确定非酒精性脂肪性肝病（NAFLD）患者的组织病理学S。MethodsThis回顾性研究包括105例活检证实的NAFLD患者。所有衰减系数（AC，dB/cm/MHz）测量值均由同一名肝病学家在肝活检当天使用市售超声系统获得。患者的平均（±标准差）年龄和体重指数分别为53（± 18）岁和27.1（± 4.1）kg/m2。影响<5%、5- 33%、33- 66%和> 66%肝细胞的脂肪变性患者数量分别为8、50、29和18例。使用专用工作站将ATI-ROI放置在三个不同位置进行AC测量：区域ROI的上边缘、肝脏包膜深度的两倍和区域ROI的下边缘。结果三个ATI ROI位置AC的AUC分别为0.734（95%置信区间[CI]：0.470-0.998），0.750（0.639-0.861）和0.878（0.788-0.968）（S ≥ 1）; 0.503（0.392-0.615），0.824（0.741-0.907）和0.809（0.724-0.895）; 0.606（0.486-0.726），0.849（0.767-0.932）和0.737（0.626-0.848）。结论为了准确评估脂肪变性分级，ATI ROI不应放置在ROI区域的上边缘。
PurposeAttenuation imaging (ATI) is a new noninvasive ultrasound technique for assessing steatosis grade (S). However, validated region-of-interest (ROI) sampling strategies are not currently available. We investigated the diagnostic performance of various ATI-ROI positions for determining histopathologic S in patients with nonalcoholic fatty liver disease (NAFLD).MethodsThis retrospective study included 105 patients with biopsy-proven NAFLD. All attenuation coefficient (AC, dB/cm/MHz) measurements were obtained by the same hepatologist using a commercially available ultrasound system on the same day as liver biopsy. Mean (± standard deviation) age and body mass index of the patients were 53 (± 18) years and 27.1 (± 4.1) kg/m2, respectively. The numbers of patients with steatosis affecting < 5%, 5–33%, 33–66%, and > 66% of hepatocytes were 8, 50, 29, and 18, respectively. The ATI-ROI was placed at three different positions for AC measurement using a dedicated workstation: the upper edge of the area ROI, twice the depth of the liver capsule, and the lower edge of the area ROI. Diagnostic performance was evaluated using the area under the receiver-operating characteristic curve (AUC).ResultsThe AUCs of AC at the three ATI-ROI positions were 0.734 (95% confidence interval [CI]: 0.470–0.998), 0.750 (0.639–0.861), and 0.878 (0.788–0.968) for S ≥ 1; 0.503 (0.392–0.615), 0.824 (0.741–0.907), and 0.809 (0.724–0.895) for S ≥ 2; and 0.606 (0.486–0.726), 0.849 (0.767–0.932), and 0.737 (0.626–0.848) for S = 3, respectively.ConclusionFor accurate steatosis grade assessment, the ATI-ROI should not be placed at the upper edge of the area ROI.
影响因子：
12.6
作者：
Lee, Dong Ho;Cho, Eun Ju;Choi, Byung Ihn
通讯作者：
Choi, Byung Ihn
影响因子：
29.4
作者：
Ajmera V;Park CC;Caussy C;Singh S;Hernandez C;Bettencourt R;Hooker J;Sy E;Behling C;Xu R;Middleton MS;Valasek MA;Faulkner C;Rizo E;Richards L;Sirlin CB;Loomba R
通讯作者：
Loomba R
影响因子：
13.5
作者：
Younossi, Zobair M.;Koenig, Aaron B.;Wymer, Mark
通讯作者：
Wymer, Mark