Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets.
Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets.
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DOI：
10.1002/ajp.22750
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发表时间：
2018-10
影响因子：
2.4
通讯作者：
French JA
中科院分区：
文献类型：
--
作者：
Cavanaugh J;Mustoe A;French JA
虽然与重要的社会伴侣分离会产生许多神经生物学和行为方面的干扰，包括行为困扰和糖皮质激素分泌增加，但重聚时的积极社会互动对于重新建立正常的关系动态和减弱生物行为应激反应至关重要。荷尔蒙催产素在一生中的生殖和行为过程中起着关键和普遍的作用，在社会纽带中发挥着特别突出的作用。在这项研究中，我们研究了在不同的社会背景(隔离；分离)和持续时间(长；短)的分离挑战之后，催产素调节与伴侣的相互作用的程度。我们证明，对催产素系统的药物操作对团聚时从属关系的表达的影响取决于分离挑战的背景和持续时间。具体地说，用催产素拮抗剂治疗的绒猴在经历了长时间的分离挑战后，在团聚时与伴侣相处的时间更短。在短暂分开的挑战中，与异性陌生人分开时，绒猴会更多地参与社交凝视，但与配偶分开时则不会。此外，受到异性陌生人的社交注视最多的绒猴在团聚时与长期伴侣相处的时间也最多。我们还发现，用催产素激动剂处理的绒猴从异性陌生人那里得到了更多的凝视，但没有从他们的配偶那里得到更多的注视。总体而言，这些结果表明，绒猴在分离过程中对社会互动的性质很敏感，随后在与长期伴侣团聚时改变了它们的从属关系的表达。这些发现进一步表明催产素是一种加强纽带的分子，它调节分离后与配偶之间正常水平的从属关系的重建，并补充了新出现的文献，该文献表明，催产素系统是关键的行为过程的基础，有助于维持持久的社会纽带。
While separation from significant social partners produces a host of neurobiological and behavioral perturbations, including behavioral distress and increased glucocorticoid production, positive social interactions upon reunion are critical for the reestablishment of normative relationship dynamics and the attenuation of the biobehavioral stress response. The hormone oxytocin has critical and pervasive roles in reproductive and behavioral processes across the lifespan, and plays a particularly prominent role in social bonding. In this study, we examined the extent that oxytocin modulates interactions with a pairmate following separation challenges that varied in both social context (isolation; separation) and duration (long; short), in marmosets. We demonstrated that the impact of pharmacological manipulations of the oxytocin system on the expression of affiliation upon reunion depended on both the context and duration of the separation challenge. Specifically, marmosets treated with an oxytocin antagonist spent less time in proximity with their pairmate upon reunion following a long-separation challenge. During the short-separation challenge, marmosets engaged in more social gaze when separated with an opposite-sex stranger, but not when separated with their mate. Furthermore, marmosets that received the most social gaze from opposite-sex strangers spent the most time in proximity with their long-term mate upon reunion. We also showed that marmosets treated with an OT agonist received increased levels of gaze from opposite-sex strangers, but not from their mate. Overall, these results suggest that marmosets are sensitive to the nature of the social interactions during separation, and subsequently alter their expression of affiliation upon reunion with their long-term mate. These findings further implicate oxytocin as a bond-enhancing molecule that regulates the reestablishment of normative levels of affiliation with a mate following separation, and add to the emerging literature that suggests the OT system underlies critical behavioral processes that contribute to the preservation of long-lasting social bonds.
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影响因子：
3.7
作者：
Birnie, Andrew K.;Taylor, Jack H.;Cavanaugh, Jon;French, Jeffrey A.
通讯作者：
French, Jeffrey A.
影响因子：
3.7
作者：
Cavanaugh J;Carp SB;Rock CM;French JA
通讯作者：
French JA
影响因子：
3.5
作者：
Boccia, Maria L.;Goursaud, Anne-Pierre S.;Pedersen, Cort A.
通讯作者：
Pedersen, Cort A.
影响因子：
3.5
作者：
Finkenwirth, Christa;Martins, Eloisa;Burkart, Judith M.
通讯作者：
Burkart, Judith M.
影响因子：
4.3
作者：
Cinini SM;Barnabe GF;Galvão-Coelho N;de Medeiros MA;Perez-Mendes P;Sousa MB;Covolan L;Mello LE
通讯作者：
Mello LE