Social isolation disrupts hippocampal neurogenesis in young non-human primates.
Social isolation disrupts hippocampal neurogenesis in young non-human primates.
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DOI：
10.3389/fnins.2014.00045
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发表时间：
2014
影响因子：
4.3
通讯作者：
Mello LE
中科院分区：
文献类型：
--
作者：
Cinini SM;Barnabe GF;Galvão-Coelho N;de Medeiros MA;Perez-Mendes P;Sousa MB;Covolan L;Mello LE
在非人类灵长类动物中，社会关系对于正常行为的发展和维持至关重要。在孤立环境中长大的动物会发展出异常的行为模式，甚至在它们后来与父母团聚时也会持续存在。在啮齿类动物中，社会隔离是一种压力事件，与海马神经发生的减少有关，但对于非人类灵长类动物在从青春期到成年期的过渡中，社会隔离的影响知之甚少。为了研究社会隔离如何影响年幼的狨猴，将它们与群体中的其他成员隔离1或3周，并评估它们的行为和海马细胞增殖的变化。我们发现，与基线水平相比，社交孤立后与焦虑相关的行为，如气味标记和运动活动增加。与此一致的是，在孤立的狨猴中，梳理毛发（一种紧张程度衰减的指示）减少了。这些结果与隔离1周和3周后皮质醇水平升高一致。社会隔离（1或3周）后，发现齿状颗粒细胞层亚颗粒区神经细胞增殖减少，brdu阳性细胞发生神经元命运的比例更小（双皮质素标记）。我们的数据与这样一种观点是一致的，即从青春期到成年期的社会剥夺会导致压力，并产生类似焦虑的行为，而这些行为反过来又可能影响神经发生，并导致长期压力状态的有害后果。
Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. In rodents, social isolation is a stressful event and is associated with a decrease in hippocampal neurogenesis but considerably less is known about the effects of social isolation in non-human primates during the transition from adolescence to adulthood. To investigate how social isolation affects young marmosets, these were isolated from other members of the colony for 1 or 3 weeks and evaluated for alterations in their behavior and hippocampal cell proliferation. We found that anxiety-related behaviors like scent-marking and locomotor activity increased after social isolation when compared to baseline levels. In agreement, grooming—an indicative of attenuation of tension—was reduced among isolated marmosets. These results were consistent with increased cortisol levels after 1 and 3 weeks of isolation. After social isolation (1 or 3 weeks), reduced proliferation of neural cells in the subgranular zone of dentate granule cell layer was identified and a smaller proportion of BrdU-positive cells underwent neuronal fate (doublecortin labeling). Our data is consistent with the notion that social deprivation during the transition from adolescence to adulthood leads to stress and produces anxiety-like behaviors that in turn might affect neurogenesis and contribute to the deleterious consequences of prolonged stressful conditions.
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影响因子：
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