Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.
Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.
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DOI：
10.1016/j.psyneuen.2015.12.027
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发表时间：
2016-04
影响因子：
3.7
通讯作者：
French JA
中科院分区：
文献类型：
--
作者：
Cavanaugh J;Carp SB;Rock CM;French JA
社会孤立是压力的主要来源，并可能导致下丘脑-垂体-肾上腺轴（HPA）的激活。一个亲密的社会伙伴的存在可以降低压力源时hpa轴反应的强度，这种现象被称为社会缓冲。由于催产素（OXT）系统在促进社会联系和亲社会行为的表达方面的作用，它已被确定为调解社会缓冲的一个候选者。本研究的目的是确定在狨猴（Callithrix jacchus）应激暴露时，OXT系统是否有助于hpa轴活动的社会缓冲。在OXT治疗（Pro8-OXT、Leu8-OXT、OXT拮抗剂和生理盐水）下，雄性和雌性狨猴与长期伴侣一起经历了标准化的心因性应激源；我们通过测量应激源的尿皮质醇来评估hpa轴的活性。我们发现阻断，而不是增强，OXT系统改变了皮质醇的模式和对压力源的接近行为。我们证明了：(1)在应激源中配偶的存在会显著减弱雌性狨猴的hpa -轴活性，而雄性狨猴则不会；(2)与生理盐水相比，经OXT拮抗剂处理的雄性狨猴在应激源上的hpa轴活性显著提高，这表明OXT系统可能会降低应激源引起的皮质醇水平升高；(3)在应激源的前30分钟内，接受OXT拮抗剂处理的雄性和雌性狨猴与配偶的亲密接触时间明显少于生理盐水处理的雄性和雌性狨猴，这表明OXT系统可能对应激源下寻求伴侣行为的表达很重要。因此，在雄性和雌性狨猴中，OXT系统和社会环境对hpa -轴对应激源的反应有不同的影响，并可能通过促进与亲密社会伙伴的接近行为的表达来调节hpa -轴的活性。
Social isolation is a major source of stress and can lead to activation of the hypothalamic-pituitary-adrenal (HPA) axis. The presence of a close social partner can reduce the magnitude of the HPA-axis response during a stressor, a phenomenon known as social buffering. The oxytocin (OXT) system has been identified as one candidate for mediating social buffering due to its role in the facilitation of social bonding and the expression of prosocial behavior. The goal of the present study was to determine whether the OXT system contributes to social buffering of HPA-axis activity in response to stressor exposure in marmoset monkeys (Callithrix jacchus). Male and female marmosets experienced a standardized psychogenic stressor with and without their long-term mate under OXT-treatments (Pro8-OXT, Leu8-OXT, OXT antagonist, and saline); we assessed HPA-axis activity by measuring urinary cortisol across the stressor. We found that blocking, but not augmenting, the OXT system altered patterns of cortisol and proximity behavior in response to a stressor. We demonstrated that (1) the presence of a mate during a stressor significantly attenuated HPA-axis activity in female, but not male, marmosets; (2) male, but not female, marmosets treated with an OXT antagonist had significantly higher HPA-axis activity across the stressor than when they were treated with saline, suggesting that the OXT system may reduce the stressor-induced rise in cortisol levels; (3) male and female marmosets treated with an OXT antagonist spent significantly less time in close proximity to their mate during the first 30 min of the stressor than when they were treated with saline, suggesting that the OXT system may be important for the expression of partner-seeking behavior during a stressor. Thus, the OXT system and social context differentially influenced how the HPA-axis responded to a stressor in male and female marmosets, and may modulate HPA-axis activity by promoting the expression of proximity behavior with a close social partner.
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影响因子：
1.3
作者：
Brosnan, Sarah F.;Talbot, Catherine F.;Zak, Paul J.
通讯作者：
Zak, Paul J.
影响因子：
3.5
作者：
Boccia, Maria L.;Goursaud, Anne-Pierre S.;Pedersen, Cort A.
通讯作者：
Pedersen, Cort A.
影响因子：
1.9
作者：
Gabor, Christopher S.;Phan, Anna;Choleris, Elena
通讯作者：
Choleris, Elena
DOI：
10.1111/j.1749-6632.2009.04541.x
发表时间：
2009-01-01
期刊：
VALUES, EMPATHY, AND FAIRNESS ACROSS SOCIAL BARRIERS
影响因子：
--
作者：
Ebstein, Richard P.;Israel, Salomon;Yirmiya, Nurit
通讯作者：
Yirmiya, Nurit
影响因子：
2.7
作者：
Bahr, NI;Palme, R;Heistermann, M
通讯作者：
Heistermann, M