Advanced glycation end products in human diabetic lens capsules.
Advanced glycation end products in human diabetic lens capsules.
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DOI：
10.1016/j.exer.2021.108704
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发表时间：
2021-09
影响因子：
3.4
通讯作者：
Nagaraj RH
中科院分区：
文献类型：
--
作者：
Rankenberg J;Rakete S;Wagner BD;Patnaik JL;Henning C;Lynch A;Glomb MA;Nagaraj RH
晚期糖基化终末产物（AGEs）随着年龄的增长在人透镜囊中蓄积。透镜囊中AGEs可增强转化生长因子β 2介导的透镜上皮细胞间质转化，提示AGEs在白内障术后后囊膜混浊中发挥作用。我们通过液相色谱-质谱法测定了白内障手术中撕囊标本中的AGEs，这些样本来自非糖尿病和糖尿病患者，有或没有视网膜病变。我们的数据显示，与非糖尿病患者相比，糖尿病患者和糖尿病视网膜病变患者的大多数AGEs水平（13个测量中有12个）没有改变。但有一个例外：glucosepane，这是显着高于糖尿病患者（6.85 pmol/μmol OH-脯氨酸）和无视网膜病变（8.32 pmol/μmol OH-脯氨酸）比非糖尿病患者（4.01 pmol/μmol OH-脯氨酸）。我们的研究解释了在几项研究中观察到的非糖尿病和糖尿病白内障患者之间后囊混浊的相似发生率。
Advanced glycation end products (AGEs) accumulate with age in human lens capsules. AGEs in lens capsules potentiate the transforming growth factor beta-2-mediated mesenchymal transition of lens epithelial cells, which suggests that they play a role in posterior capsule opacification after cataract surgery. We measured AGEs by liquid chromatography-mass spectrometry in capsulorhexis specimens obtained during cataract surgery from nondiabetic and diabetic patients with and without established retinopathy. Our data showed that the levels of most AGEs (12 out of 13 measured) were unaltered in diabetic patients and diabetic patients with retinopathy compared to nondiabetic patients. There was one exception: glucosepane, which was significantly higher in diabetic patients, both with (6.85 pmol/μmol OH-proline) and without retinopathy (8.32 pmol/μmol OH-proline), than in nondiabetic patients (4.01 pmol/μmol OH-proline). Our study provides an explanation for the similar incidence of posterior capsule opacification between nondiabetic and diabetic cataract patients observed in several studies.
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影响因子：
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作者：
Mamuya FA;Wang Y;Roop VH;Scheiblin DA;Zajac JC;Duncan MK
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影响因子：
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DOI：
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影响因子：
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10.1016/j.matbio.2009.12.004
发表时间：
2010-04
期刊：
Matrix biology : journal of the International Society for Matrix Biology
影响因子：
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作者：
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通讯作者：
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