Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
复制标题
DOI：
10.1016/j.immuni.2012.01.017
复制
发表时间：
2012-03-23
期刊：
影响因子：
32.4
通讯作者：
Butcher EC
中科院分区：
文献类型：
--
作者：
Hadeiba H;Lahl K;Edalati A;Oderup C;Habtezion A;Pachynski R;Nguyen L;Ghodsi A;Adler S;Butcher EC
中枢耐受性可以通过外周树突状细胞（DC）介导，其将无害抗原（Ags）转运到胸腺，然后呈递给发育中的T细胞，但负责的DC亚群仍不明确。未成熟浆细胞样dc （pDCs）表达CCR9，一种参与T细胞前体向胸腺迁移的趋化因子受体。我们在这里证明CCR9介导内源性或静脉输注的pDCs有效进入胸腺。由toll样受体（TLR）配体激活的pDCs下调CCR9并失去其返回胸腺的能力。此外，内源性pDCs接受皮下注射的荧光银，在没有TLR信号的情况下，以依赖ccr9的方式将银转运到胸腺。注射后，载银的pDCs有效地删除了ag特异性胸腺细胞，这种胸腺克隆删除需要ccr9介导的归巢，并被感染信号阻止。因此，外周pDCs可以通过ccr9依赖性外周Ags的转运和随后ag反应性胸腺细胞的缺失来促进免疫耐受。
Central tolerance can be mediated by peripheral dendritic cells (DCs) that transport innocuous antigens (Ags) to the thymus for presentation to developing T cells, but the responsible DC subsets remain poorly defined. Immature plasmacytoid DCs (pDCs) express CCR9, a chemokine receptor involved in migration of T cell precursors to the thymus. We show here that CCR9 mediated efficient thymic entry of endogenous or i.v. transfused pDCs. pDCs activated by Toll-like receptor (TLR) ligands downregulated CCR9 and lost their ability to home to the thymus. Moreover, endogenous pDCs took up subcutaneously injected fluorescent Ag and, in the absence of TLR signals, transported Ag to the thymus in a CCR9-dependent fashion. Injected, Ag-loaded pDCs effectively deleted Ag-specific thymocytes, and this thymic clonal deletion required CCR9-mediated homing and was prevented by infectious signals. Thus peripheral pDCs can contribute to immune tolerance through CCR9-dependent transport of peripheral Ags and subsequent deletion of Ag-reactive thymocytes.
登录
查看更多内容
DOI：
10.1084/jem.20020045
发表时间：
2002-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gilliet M;Boonstra A;Paturel C;Antonenko S;Xu XL;Trinchieri G;O'Garra A;Liu YJ
通讯作者：
Liu YJ
胸腺归巢外周树突状细胞构成稳态胸腺中树突状细胞的三个主要亚群中的两个。
影响因子：
15.3
作者：
Li, JiChu;Park, JooHung;Foss, Deborah;Goldschneider, Irving
通讯作者：
Goldschneider, Irving
影响因子：
30.5
作者：
Liu, Kang;Waskow, Claudia;Nussenzweig, Michel
通讯作者：
Nussenzweig, Michel
影响因子：
30.5
作者：
Aschenbrenner, Katharina;D'Cruz, Louise M.;Klein, Ludger
通讯作者：
Klein, Ludger
影响因子：
56.9
作者：
Anderson, MS;Venanzi, ES;Mathis, D
通讯作者：
Mathis, D