Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus.
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus.
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胸腺归巢外周树突状细胞构成稳态胸腺中树突状细胞的三个主要亚群中的两个。
DOI：
10.1084/jem.20082232
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发表时间：
2009-03-16
影响因子：
15.3
通讯作者：
Goldschneider, Irving
中科院分区：
文献类型：
--
作者：
Li, JiChu;Park, JooHung;Foss, Deborah;Goldschneider, Irving
正常小鼠胸腺中的许多树突状细胞（DC）是由共同的T细胞/DC祖细胞在胸腺内产生的。然而，我们以前的工作表明，至少有50%的胸腺树突状细胞起源独立于这些祖细胞。我们现在正式证明了联体，过继转移，和发育研究，胸腺DC的三个主要子集中的两个起源于胸腺外，并不断迁移到胸腺，在那里他们占据了有限数量的微环境的壁龛。胸腺归巢DC由未成熟浆细胞样DC（pDC）和常规DC的信号调节蛋白α阳性（Sirpα+）CD 11b + CD 8 α−亚群（cDC）组成，两者都可以摄取并转运循环抗原至胸腺。胸腺内来源的cDC主要是Sirpα− CD 11b − CD 8 αhi细胞。到达胸腺后，迁移的pDC扩增并上调CD 11 c、主要组织相容性复合物II（MHC II）和CD 8 α，但保持其浆细胞样形态。相反，迁移性cDCs广泛增殖，上调CD 11 c、MHC II和CD 86，并表达树突状突起。这些发现可能的功能影响进行了讨论。
Many dendritic cells (DCs) in the normal mouse thymus are generated intrathymically from common T cell/DC progenitors. However, our previous work suggested that at least 50% of thymic DCs originate independently of these progenitors. We now formally demonstrate by parabiotic, adoptive transfer, and developmental studies that two of the three major subsets of thymic DCs originate extrathymically and continually migrate to the thymus, where they occupy a finite number of microenvironmental niches. The thymus-homing DCs consisted of immature plasmacytoid DCs (pDCs) and the signal regulatory protein α–positive (Sirpα+) CD11b+ CD8α− subset of conventional DCs (cDCs), both of which could take up and transport circulating antigen to the thymus. The cDCs of intrathymic origin were mostly Sirpα− CD11b− CD8αhi cells. Upon arrival in the thymus, the migrant pDCs enlarged and up-regulated CD11c, major histocompatibility complex II (MHC II), and CD8α, but maintained their plasmacytoid morphology. In contrast, the migrant cDCs proliferated extensively, up-regulated CD11c, MHC II, and CD86, and expressed dendritic processes. The possible functional implications of these findings are discussed.
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影响因子：
4.4
作者：
Chiffoleau, E;Bériou, G;Cuturi, MC
通讯作者：
Cuturi, MC
影响因子：
4.4
作者：
Diao, Jun;Winter, Erin;Cattral, Mark S.
通讯作者：
Cattral, Mark S.
影响因子：
15.9
作者：
Duncan, SR;Capetanakis, NG;Theofilopoulos, AN
通讯作者：
Theofilopoulos, AN
影响因子：
20.3
作者：
Ferrero, I;Held, W;MacDonald, HR
通讯作者：
MacDonald, HR
DOI：
10.1084/jem.191.3.435
发表时间：
2000-02-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Huang FP;Platt N;Wykes M;Major JR;Powell TJ;Jenkins CD;MacPherson GG
通讯作者：
MacPherson GG