The pharmacology of plant virus nanoparticles.
The pharmacology of plant virus nanoparticles.
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DOI：
10.1016/j.virol.2021.01.012
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发表时间：
2021-04
期刊：
影响因子：
3.7
通讯作者：
Steinmetz NF
中科院分区：
文献类型：
--
作者：
Nkanga CI;Steinmetz NF
纳米粒子在医学上的应用已经取得了巨大的进步，为健康问题提供了新的解决方案。基于植物病毒的纳米颗粒（VNPs）可以被重新利用和改造为靶向药物传递和成像的智能生物载体，这一发现为改善各种疾病的治疗和诊断管理启动了广泛的研究。有证据表明，VNPs是一种具有转化开发潜力的高价值纳米载体。这主要是由于它们独特的特性，包括结构均匀性、易于制造和通过表达、化学生物学和自组装实现功能化。虽然开发管道正在迅速发展，许多报告都集中在工程和制造方面，以定制VNPs的特性和功效，但很少有研究集中在深入了解这种新型纳米技术平台的纳米毒性。在此，我们讨论了VNPs的药理学，作为配方和给药途径的功能。VNPs在其作为治疗佐剂或纳米载体辅料的应用背景下进行审查，以启动，增强，减弱或阻碍配方的毒性。然而，数据总结也强调了细致的VNP结构-纳米毒性研究的必要性，以提高我们对其体内命运和药理学特征的理解，为将基于VNP的配方转化为临床环境铺平道路。
The application of nanoparticles for medical purposes has made enormous strides in providing new solutions to health problems. The observation that plant virus-based nanoparticles (VNPs) can be repurposed and engineered as smart bio-vehicles for targeted drug delivery and imaging has launched extensive research for improving the therapeutic and diagnostic management of various diseases. There is evidence that VNPs are promising high value nanocarriers with potential for translational development. This is mainly due to their unique features, encompassing structural uniformity, ease of manufacture and functionalization by means of expression, chemical biology and self-assembly. While the development pipeline is moving rapidly, with many reports focusing on engineering and manufacturing aspects to tailor the properties and efficacy of VNPs, fewer studies have focused on gaining insights into the nanotoxicity of this novel platform nanotechnology. Herein, we discuss the pharmacology of VNPs as a function of formulation and route of administration. VNPs are reviewed in the context of their application as therapeutic adjuvants or nanocarrier excipients to initiate, enhance, attenuate or impede the formulation’s toxicity. The summary of the data however also underlines the need for meticulous VNP structure-nanotoxicity studies to improve our understanding of their in vivo fates and pharmacological profiles to pave the way for translation of VNP-based formulations into the clinical setting.
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DOI：
10.1016/j.ejpb.2020.08.012
发表时间：
2020-10-01
影响因子：
4.9
作者：
Berardi, Alberto;Castells-Graells, Roger;Lomonossoff, George P.
通讯作者：
Lomonossoff, George P.
影响因子：
3.2
作者：
Bruckman, Michael A.;Kaur, Gagandeep;Wang, Qian
通讯作者：
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影响因子：
16.1
作者：
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通讯作者：
McNeil SE
影响因子：
14
作者：
Adriani, Giulia;de Tullio, Marco Donato;Ferrari, Mauro;Hussain, Fazle;Pascazio, Giuseppe;Liu, Xuewu;Decuzzi, Paolo
通讯作者：
Decuzzi, Paolo
影响因子：
3.8
作者：
Atabekov, Joseph;Nikitin, Nikolai;Karpova, Olga
通讯作者：
Karpova, Olga