Increased risk of osteoarthritis in patients with atopic disease.
Increased risk of osteoarthritis in patients with atopic disease.
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DOI：
10.1136/ard-2022-223640
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发表时间：
2023-06
影响因子：
27.4
通讯作者：
中科院分区：
文献类型：
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作者：
确定特应性疾病患者与匹配的非暴露患者的骨关节炎（OA）发生率。我们进行了一项回顾性队列研究，使用Optum的去识别临床数据集市（CDM）的索赔数据（2003年1月至2019年6月）和斯坦福大学研究资料库（STARR）的电子健康记录数据（2010年1月至2020年12月）进行倾向评分匹配。我们纳入了暴露于或未暴露于特应性疾病的既无OA或炎性关节炎的成人患者。主要结局是发生OA事件。在Optum CDM中，我们确定了117346例哮喘或特应性皮炎暴露患者（平均年龄52岁; 60%为女性）和1247196例非暴露患者（平均年龄50岁; 48%为女性）。倾向评分匹配后（每组n=1 09 899），哮喘或特应性皮炎患者的OA发生率（26. 9/1000人-年）高于非暴露患者（19. 1/1000人-年），发生OA的校正比值比（aOR）为1. 58（95% CI 1. 55 - 1. 62）。与未暴露患者相比，哮喘和特应性皮炎患者的这种效应更为明显（aOR=2.15; 95% CI 1.93 - 2.39），与慢性阻塞性肺疾病患者相比，哮喘患者的这种效应更为明显（aOR=1.83; 95% CI 1.73 - 1.95）。我们在一个独立的数据集（STARR）中复制了我们的结果，该数据集提供了更丰富的体重指数数据。STARR中哮喘或特应性皮炎患者与未暴露患者发生OA的aOR为1.42（95% CI 1.36 - 1.48）。本研究表明，特应性疾病患者OA的发病率增加。未来的干预性研究可能会考虑针对过敏途径预防或治疗OA。
To determine the incidence of osteoarthrits (OA) in patients with atopic disease compared with matched non-exposed patients. We conducted a retrospective cohort study with propensity score matching using claims data from Optum’s de-identified Clinformatics Data Mart (CDM) (January 2003 to June 2019) and electronic health record data from the Stanford Research Repository (STARR) (January 2010 to December 2020). We included adult patients without pre-existing OA or inflammatory arthritis who were exposed to atopic disease or who were non-exposed. The primary outcome was the development of incident OA. In Optum CDM, we identified 117 346 exposed patients with asthma or atopic dermatitis (mean age 52 years; 60% female) and 1 247 196 non-exposed patients (mean age 50 years; 48% female). After propensity score matching (n=1 09 899 per group), OA incidence was higher in patients with asthma or atopic dermatitis (26.9 per 1000 person-years) compared with non-exposed patients (19.1 per 1000 person-years), with an adjusted odds ratio (aOR) of 1.58 (95% CI 1.55 to 1.62) for developing OA. This effect was even more pronounced in patients with both asthma and atopic dermatitis compared with non-exposed patients (aOR=2.15; 95% CI 1.93 to 2.39) and in patients with asthma compared with patients with chronic obstructive pulmonary disease (aOR=1.83; 95% CI 1.73 to 1.95). We replicated our results in an independent dataset (STARR), which provided the added richness of body mass index data. The aOR of developing OA in patients with asthma or atopic dermatitis versus non-exposed patients in STARR was 1.42 (95% CI 1.36 to 1.48). This study demonstrates an increased incidence of OA in patients with atopic disease. Future interventional studies may consider targeting allergic pathways for the prevention or treatment of OA.
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DOI：
10.1038/nrrheum.2016.136
发表时间：
2016-10
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
Robinson WH;Lepus CM;Wang Q;Raghu H;Mao R;Lindstrom TM;Sokolove J
通讯作者：
Sokolove J
影响因子：
7
作者：
de Lange-Brokaar, B. J. E.;Kloppenburg, M.;Ioan-Facsinay, A.
通讯作者：
Ioan-Facsinay, A.
影响因子：
4.7
作者：
Marshall, Deborah A.;Vanderby, Sonia;Noseworthy, Tom
通讯作者：
Noseworthy, Tom
影响因子：
--
作者：
Murphy L;Schwartz TA;Helmick CG;Renner JB;Tudor G;Koch G;Dragomir A;Kalsbeek WD;Luta G;Jordan JM
通讯作者：
Jordan JM
影响因子：
5.3
作者：
Forster, T;Chapman, K;Loughlin, J
通讯作者：
Loughlin, J