Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice.
Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice.
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在胎儿生活中或成年期间暴露于低剂量的双酚A会改变小鼠的母性行为。
DOI：
10.1289/ehp.02110s3415
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发表时间：
2002-06
影响因子：
10.4
通讯作者：
vom Saal FS
中科院分区：
文献类型：
--
作者：
Palanza PL;Howdeshell KL;Parmigiani S;vom Saal FS
哺乳动物的母性行为是哺乳期母体和其发育中的后代之间复杂相互作用的结果。母婴相互作用的任何组成部分的轻微扰动都可能导致母亲和/或后代行为的改变。我们研究了雌性CD-1小鼠在胎儿期和/或成年期妊娠后期暴露于雌激素化学物质双酚A（BPA）对随后的母体行为的影响。在妊娠第14 - 18天期间，向妊娠雌性动物喂食每日剂量的玉米油（对照）或10 μ g/kg体重BPA。作为成年人，将产前处理的雌性后代定时交配，并在妊娠第14 - 18天再次喂食玉米油（对照）或相同剂量的BPA，从而产生四个处理组：对照组，产前BPA暴露组，成年BPA暴露组，以及产前和成年BPA暴露组。然后在出生后第2 - 15天观察母体行为，并检查后代的反射反应。与对照组相比，在胎儿或成年期暴露于BPA的母鼠花在护理幼崽上的时间更少，花在巢外的时间更多。在胎儿期和成年期暴露于BPA的女性与对照组没有显著差异。在暴露于BPA的雌性动物的后代中未观察到出生后反射发育的变化。在母性行为中观察到的变化可能是BPA对母性行为启动的神经内分泌底物的直接影响的结果。
Maternal behavior in mammals is the result of a complex interaction between the lactating dam and her developing offspring. Slight perturbations of any of the components of the mother-infant interaction may result in alterations of the behavior of the mother and/or of the offspring. We studied the effects of exposure of female CD-1 mice to the estrogenic chemical bisphenol A (BPA) during fetal life and/or in adulthood during the last part of pregnancy on subsequent maternal behavior. Pregnant females were fed daily doses of corn oil (controls) or 10 microg/kg body weight BPA during gestation days 14-18. As adults, the prenatally treated female offspring were time-mated and again fed either corn oil (controls) or the same doses of BPA on gestation days 14-18, resulting in four treatment groups: controls, prenatal BPA exposure, adult BPA exposure, and both prenatal and adult BPA exposure. Maternal behavior was then observed on postnatal days 2-15 and reflex responses were examined in the offspring. Dams exposed to BPA either as fetuses or in adulthood spent less time nursing their pups and more time out of the nest compared with the control group. Females exposed to BPA both as fetuses and in adulthood did not significantly differ from controls. No alterations in postnatal reflex development were observed in the offspring of the females exposed to BPA. The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior.
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DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
DOI：
10.1046/j.1525-1373.2000.22402.x
发表时间：
2000-06-01
影响因子：
--
作者：
Gupta, C
通讯作者：
Gupta, C
DOI：
10.1152/ajpregu.2000.279.5.r1899
发表时间：
2000-11-01
影响因子：
2.8
作者：
Brabham, T;Phelka, A;Vázquez, DM
通讯作者：
Vázquez, DM
影响因子：
56.9
作者：
Liu, D;Diorio, J;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
3.6
作者：
Farabollini, F;Porrini, S;Dessì-Fulgheri, F
通讯作者：
Dessì-Fulgheri, F