Role of matrix vesicles in biomineralization.

Role of matrix vesicles in biomineralization.
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DOI:
10.1016/j.bbagen.2009.09.006
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发表时间:
2009-12
影响因子:
3
通讯作者:
Golub, Ellis E.
Golub, Ellis E.
中科院分区:
生物学3区
文献类型:
--
作者:
Golub, Ellis E.

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基质囊泡与钙化软骨、骨和牙本质的矿化有关已有40多年的历史。在此期间,它们在羟基磷灰石矿物成核中的确切作用,以及它随后与有机基质中胶原原纤维的关联一直存在争议,并且仍然存在争议。最近提出了几个假设来更详细地解释基质囊泡在生物矿化中的作用。这篇综述将总结最近的进展,并在这些有趣和神秘的细胞外细胞器正在进行的传奇中提出问题。
Matrix vesicles have been implicated in the mineralization of calcified cartilage, bone and dentin for more than 40 years. During this period, their exact role, if any in the nucleation of hydroxyapatite mineral, and its subsequent association with the collagen fibrils in the organic matrix has been debated and remains controversial. Several hypotheses have been recently introduced to explain in greater detail how matrix vesicles function in biomineralization. This review will summarize recent advances, and open questions in the ongoing saga of these interesting and enigmatic extracellular organelles.
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发表时间: 1967-10
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