The Fluctuation Trend of Serum Anti-SARS-CoV-2 IgM/IgG Antibodies Seroprevalence in the Non-COVID-19 Infected Population and Correlation with Peripheral Blood Leukocyte Parameters in Beijing, China, 2021: A Real-World Study.
The Fluctuation Trend of Serum Anti-SARS-CoV-2 IgM/IgG Antibodies Seroprevalence in the Non-COVID-19 Infected Population and Correlation with Peripheral Blood Leukocyte Parameters in Beijing, China, 2021: A Real-World Study.
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DOI：
10.3390/vaccines10040571
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发表时间：
2022-04-07
期刊：
影响因子：
7.8
通讯作者：
Cui, Liyuan
中科院分区：
文献类型：
--
作者：
Wang, Pan;Yang, Nan;Xue, Yuting;Zhou, Jiansuo;Wu, Yonghua;Wang, Tiancheng;Cui, Liyuan
自2019年以来，2019冠状病毒病（COVID-19）全球大流行已造成3亿多例病例和500万人死亡。接种疫苗已被广泛认为是预防和控制这种疾病的最有效措施。然而，对非covid -19感染人群灭活疫苗后血清抗sars - cov -2 IgM/IgG水平及其与外周血白细胞的关系了解甚少。本研究在位于中国北京的北京大学第三医院共招募了16,335名男性和22302名女性参与者。探讨血清抗sars - cov -2受体结合域（RBD） IgM/IgG水平和血清阳性率及其与外周血白细胞分型的关系。随着北京地区COVID-19疫苗全免疫接种次数和百分比的增加，血清抗sars - cov -2 IgG抗体水平和血清阳性率显著升高（p < 0.01）。60岁及以上人群血清抗sars - cov -2 IgG抗体水平显著低于18~60岁人群（p < 0.01），血清抗sars - cov -2 IgG抗体水平与外周血淋巴细胞计数呈正相关。血清抗sars - cov -2 IgM/IgG抗体和外周血血液学指标的检测可能提示和帮助了解疫苗接种的适应性免疫反应。
Since 2019, the coronavirus disease 2019 (COVID-19) global pandemic has caused more than 300 million cases of disease and 5 million deaths. Vaccination has been widely accepted as the most effective measure for the prevention and control of this disease. However, there is little understanding about serum anti-SARS-CoV-2 IgM/IgG levels after inactivated vaccination as well as the relationship with peripheral blood leukocytes in the non-COVID-19 infected population. A total of 16,335 male and 22,302 female participants were recruited in this study, which was conducted in the Peking University Third Hospital located in Beijing (China). The level and seroprevalence of serum anti-SARS-CoV-2 receptor-binding domain (RBD) IgM/IgG and the association with peripheral blood leukocytes classification were investigated. With an increase in the number and percentage of full immunization of COVID-19 vaccinations in Beijing, serum anti-SARS-CoV-2 IgG antibodies levels and seroprevalence were significantly elevated (p < 0.01). The serum anti-SARS-CoV-2 IgG antibodies of 60 years and older persons were significantly lower than that of individuals that are 18~60 years old (p < 0.01), and there was a positive relationship between serum anti-SARS-CoV-2 IgG antibodies levels and peripheral blood lymphocyte count. The investigation of serum anti-SARS-CoV-2 IgM/IgG antibodies and the peripheral hematological index may prompt and help understand the adaptive immune response of vaccination.
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影响因子：
8.1
作者：
Zheng W;Yan X;Zhao Z;Yang J;Yu H
通讯作者：
Yu H
DOI：
10.1016/j.cca.2021.09.022
发表时间：
2021-12
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Raposo F;Lippi G
通讯作者：
Lippi G
人类 IgM 和 IgG 对灭活 SARS-CoV-2 疫苗的反应
影响因子：
2.4
作者：
Banga Ndzouboukou JL;Zhang YD;Lei Q;Lin XS;Yao ZJ;Fu H;Yuan LY;Fan XL
通讯作者：
Fan XL
影响因子：
6.8
作者：
Irsara, Christian;Egger, Alexander E.;Hoermann, Gregor
通讯作者：
Hoermann, Gregor
影响因子：
7.3
作者：
Li Z;Xiang T;Liang B;Deng H;Wang H;Feng X;Quan X;Wang X;Li S;Lu S;Yang X;Wang B;Zelinskyy G;Trilling M;Sutter K;Lu M;Dittmer U;Yang D;Zheng X;Liu J
通讯作者：
Liu J