Association Between COVID-19 Pregnant Women Symptoms Severity and Placental Morphologic Features.
Association Between COVID-19 Pregnant Women Symptoms Severity and Placental Morphologic Features.
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DOI：
10.3389/fimmu.2021.685919
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发表时间：
2021
影响因子：
7.3
通讯作者：
de Noronha L
中科院分区：
文献类型：
--
作者：
Rebutini PZ;Zanchettin AC;Stonoga ETS;Prá DMM;de Oliveira ALP;Dezidério FDS;Fonseca AS;Dagostini JCH;Hlatchuk EC;Furuie IN;Longo JDS;Cavalli BM;Dino CLT;Dias VMCH;Percicote AP;Nogueira MB;Raboni SM;de Carvalho NS;Machado-Souza C;de Noronha L
自从SARS-CoV-2大流行开始以来，很少有文献描述SARS-CoV-2阳性孕妇胎盘的形态和形态计量学特征。改变，如胎盘重量低，绒毛成熟加速，蜕膜血管病变，梗塞，胎儿胎盘血管血栓形成，和慢性组织细胞性间隔炎(CHI)已被描述。分析非典-CoV-2感染孕妇(新冠肺炎组)与非感染孕妇(对照组)的临床资料及胎盘形态计量学变化，并与年龄、合并症相匹配的非感染孕妇胎盘进行比较。新冠肺炎组和对照组的患者在母亲年龄、胎龄和合并症方面匹配。采用阿姆斯特丹胎盘研讨会小组共识声明对胎盘进行形态分析。定量形态计量学评价包括绒毛周径、三级绒毛数目、绒毛出芽和结节数、绒毛纤维蛋白沉积、天狼星红染色观察绒毛内I型和III型胶原沉积。免疫组织化学方法检测绒毛内Hofbauer细胞(HC)的数量。与对照组相比，新冠肺炎组中有症状的女性更有可能至少有一种共病，演变为早产和婴儿死亡，并且她们的概念中有SARS-CoV-2RNA检测阳性。与对照组相比，新冠肺炎组的胎盘更容易出现母体和胎儿血管灌注不良的特征。在新冠肺炎组中，有症状的女性胎盘更有可能出现气。形态计量学分析后未发现显著结果。有症状的SARS-CoV-2感染的孕妇，特别是病程严重的孕妇，更有可能表现出不良的胎儿结局，母婴血管灌注不良和CHI的组织病理学表现略多见。新冠肺炎组胎盘的形态计量学变化似乎与对照组观察到的没有什么不同，只要母亲的年龄、胎龄和合并症是配对的。新冠肺炎组仅绒毛纤维蛋白沉积更明显(p=0.08)。CD68免疫组织化学检测的HC/绒毛数目在两组间无差异。
Since the beginning of the pandemic, few papers describe the placenta’s morphological and morphometrical features in SARS-CoV-2–positive pregnant women. Alterations, such as low placental weight, accelerated villous maturation, decidual vasculopathy, infarcts, thrombosis of fetal placental vessels, and chronic histiocytic intervillositis (CHI), have been described. To analyze clinical data and the placental morphological and morphometric changes of pregnant women infected with SARS-CoV-2 (COVID-19 group) in comparison with the placentas of non-infected pregnant women, matched for maternal age and comorbidities, besides gestational age of delivery (Control group). The patients in the COVID-19 and the Control group were matched for maternal age, gestational age, and comorbidities. The morphological analysis of placentas was performed using Amsterdam Placental Workshop Group Consensus Statement. The quantitative morphometric evaluation included perimeter diameter and number of tertiary villi, number of sprouts and knots, evaluation of deposition of villous fibrin, and deposition of intra-villous collagen I and III by Sirius Red. Additionally, Hofbauer cells (HC) were counted within villi by immunohistochemistry with CD68 marker. Compared to controls, symptomatic women in the COVID-19 group were more likely to have at least one comorbidity, to evolve to preterm labor and infant death, and to have positive SARS-CoV-2 RNA testing in their concepts. Compared to controls, placentas in the COVID-19 group were more likely to show features of maternal and fetal vascular malperfusion. In the COVID-19 group, placentas of symptomatic women were more likely to show CHI. No significant results were found after morphometric analysis. Pregnant women with symptomatic SARS-CoV-2 infection, particularly with the severe course, are more likely to exhibit an adverse fetal outcome, with slightly more frequent histopathologic findings of maternal and fetal vascular malperfusion, and CHI. The morphometric changes found in the placentas of the COVID-19 group do not seem to be different from those observed in the Control group, as far as maternal age, gestational age, and comorbidities are paired. Only the deposition of villous fibrin could be more accentuated in the COVID-19 group (p = 0.08 borderline). The number of HC/villous evaluated with CD68 immunohistochemistry did not show a difference between both groups.
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影响因子：
5.2
作者：
de Noronha L;Zanluca C;Burger M;Suzukawa AA;Azevedo M;Rebutini PZ;Novadzki IM;Tanabe LS;Presibella MM;Duarte Dos Santos CN
通讯作者：
Duarte Dos Santos CN
影响因子：
8.4
作者：
Amzat, Jimoh;Aminu, Kafayat;Danjibo, Maryann C.
通讯作者：
Danjibo, Maryann C.
影响因子：
5
作者：
Lippi, Giuseppe;Plebani, Mario;Henry, Brandon Michael
通讯作者：
Henry, Brandon Michael
DOI：
10.1016/j.ajogmf.2020.100118
发表时间：
2020-05-01
影响因子：
6.3
作者：
Breslin, Noelle;Baptiste, Caitlin;Goffman, Dena
通讯作者：
Goffman, Dena
影响因子：
9.8
作者：
Lokken, Erica M.;Walker, Christie L.;Waldorf, Kristina M. Adams
通讯作者：
Waldorf, Kristina M. Adams