Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response.
Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response.
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DOI：
10.3390/cancers13174318
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发表时间：
2021-08-26
期刊：
影响因子：
5.2
通讯作者：
Rizvi I
中科院分区：
文献类型：
--
作者：
Rickard BP;Conrad C;Sorrin AJ;Ruhi MK;Reader JC;Huang SA;Franco W;Scarcelli G;Polacheck WJ;Roque DM;Del Carmen MG;Huang HC;Demirci U;Rizvi I
腹部积存过多的液体，通常表明底层组织的功能异常或疾病，如癌症。这种积液，或称腹水，在晚期卵巢癌患者中比其他类型的癌症更常发生。腹水的存在表明晚期卵巢癌患者的预后最差，但对这些令人沮丧的结果的原因知之甚少。这篇综述讨论了目前对腹水的理解，从卵巢癌和腹水的概述开始，然后描述了用于分析腹水成分的工具以及这些成分如何调节卵巢癌生物学。对腹水的机械效应和机械应力对治疗阻力的影响的观点提供。最后，腹水的治疗方案和发展新的治疗策略，以改善结果的机会进行了讨论。腹水是指由于潜在病理（如转移性癌症）导致的腹膜内液体的异常积聚。在所有癌症中，晚期上皮性卵巢癌最常与恶性腹水的产生相关，是妇科恶性肿瘤死亡的主要原因。尽管几十年来的证据表明，腹膜积液预示着癌症患者预后最差，但恶性腹水在促进转移和治疗抵抗中的作用仍然知之甚少。本文综述了目前对恶性腹水的认识，重点是卵巢癌。第一部分概述了卵巢癌的异质性和恶性腹水的病理生理。接下来，讨论了用于表征恶性腹水的细胞和非细胞成分的分析方法，以及这些成分在调节细胞生物学中的作用。然后，综述提供了肿瘤在恶性腹水存在时所承受的压力和力量以及物理压力对治疗抵抗的影响的观点。然后讨论了恶性腹水的治疗选择，包括手术，药理和光化学干预，以突出肿瘤药物发现，设备开发和物理科学界面的挑战和机遇。
Accumulation of excess fluid in the abdomen typically indicates abnormal function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or ascites, occurs more frequently in patients with advanced-stage ovarian cancer than any other type of cancer. The presence of ascites indicates the poorest outcomes for patients with advanced stage ovarian cancer, but little is known about the reasons for these dismal outcomes. This review discusses the current understanding of ascites, starting with an overview of ovarian cancer and ascites, followed by a description of the tools used to analyze the components of ascites and how these components modulate ovarian cancer biology. A perspective on the mechanical effects of ascites and the impact of mechanical stress on treatment resistance is provided. Lastly, treatment options for ascites and opportunities to develop new therapeutic strategies to improve outcomes are discussed. Ascites refers to the abnormal accumulation of fluid in the peritoneum resulting from an underlying pathology, such as metastatic cancer. Among all cancers, advanced-stage epithelial ovarian cancer is most frequently associated with the production of malignant ascites and is the leading cause of death from gynecologic malignancies. Despite decades of evidence showing that the accumulation of peritoneal fluid portends the poorest outcomes for cancer patients, the role of malignant ascites in promoting metastasis and therapy resistance remains poorly understood. This review summarizes the current understanding of malignant ascites, with a focus on ovarian cancer. The first section provides an overview of heterogeneity in ovarian cancer and the pathophysiology of malignant ascites. Next, analytical methods used to characterize the cellular and acellular components of malignant ascites, as well the role of these components in modulating cell biology, are discussed. The review then provides a perspective on the pressures and forces that tumors are subjected to in the presence of malignant ascites and the impact of physical stress on therapy resistance. Treatment options for malignant ascites, including surgical, pharmacological and photochemical interventions are then discussed to highlight challenges and opportunities at the interface of drug discovery, device development and physical sciences in oncology.
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化疗后卵巢癌腹水衍生的肿瘤细胞的独特蛋白质组特征。
影响因子：
4.6
作者：
Ahmed N;Greening D;Samardzija C;Escalona RM;Chen M;Findlay JK;Kannourakis G
通讯作者：
Kannourakis G
影响因子：
4.4
作者：
Adhikary T;Wortmann A;Finkernagel F;Lieber S;Nist A;Stiewe T;Wagner U;Müller-Brüsselbach S;Reinartz S;Müller R
通讯作者：
Müller R
影响因子：
5.2
作者：
Alharbi M;Lai A;Sharma S;Kalita-de Croft P;Godbole N;Campos A;Guanzon D;Salas-Burgos A;Carrion F;Zuñiga FA;Perrin L;He Y;Pejovic T;Winters C;Morgan T;Hooper JD;Rice GE;Salomon C
通讯作者：
Salomon C
影响因子：
--
作者：
Austefjord MW;Gerdes HH;Wang X
通讯作者：
Wang X
影响因子：
4.3
作者：
Baenke F;Peck B;Miess H;Schulze A
通讯作者：
Schulze A