Neuromodulation of hippocampal long-term synaptic plasticity.
Neuromodulation of hippocampal long-term synaptic plasticity.
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DOI：
10.1016/j.conb.2018.08.009
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发表时间：
2019-03
影响因子：
5.7
通讯作者：
Mellor JR
中科院分区：
文献类型：
--
作者：
Palacios-Filardo J;Mellor JR
乙酰胆碱、去甲肾上腺素、多巴胺和血清素都有助于长期的突触可塑性。神经调节剂通过共同和不同的机制促进长期突触可塑性。常见的机制包括NMDA受体通过钾通道抑制、胶质传递和去抑制促进。不同的机制包括去抑制和时空神经调节剂释放的多样性。包括乙酰胆碱、去甲肾上腺素、多巴胺和血清素在内的多种神经调节剂在不确定性下被释放，以将注意力集中在预测结果与观察到的现实不符的事件上。在这些情况下，内部表征需要更新，这一过程需要长期的突触可塑性。通过各种共同和不同的机制，最近表明所有这些神经调节剂促进海马内长期突触可塑性的诱导和/或表达。在生理条件下，这可能对可塑性的阈上诱导至关重要，赋予神经调节剂门控功能，并提供一种机制，通过这种机制，神经调节剂可以用相关信息有针对性地更新记忆，以提高未来预测的准确性。
Acetylcholine, noradrenaline, dopamine and serotonin all facilitate long-term synaptic plasticity. Neuromodulators facilitate long-term synaptic plasticity by common and divergent mechanisms. Common mechanisms include NMDA receptor facilitation by potassium channel inhibition, gliotransmission and disinhibition. Divergent mechanisms include diversity of disinhibition and temporal and spatial neuromodulator release. Multiple neuromodulators including acetylcholine, noradrenaline, dopamine and serotonin are released in response to uncertainty to focus attention on events where the predicted outcome does not match observed reality. In these situations, internal representations need to be updated, a process that requires long-term synaptic plasticity. Through a variety of common and divergent mechanisms, it is recently shown that all these neuromodulators facilitate the induction and/or expression of long-term synaptic plasticity within the hippocampus. Under physiological conditions, this may be critical for suprathreshold induction of plasticity endowing neuromodulators with a gating function and providing a mechanism by which neuromodulators enable the targeted updating of memory with relevant information to improve the accuracy of future predictions.
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