CALD1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancers.
CALD1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancers.
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CALD 1是一种预后生物标志物，与胃癌的免疫浸润相关。
DOI：
10.1016/j.heliyon.2021.e07257
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发表时间：
2021-06
期刊：
影响因子：
4
通讯作者：
Lu R
中科院分区：
文献类型：
--
作者：
Liu Y;Xie S;Zhu K;Guan X;Guo L;Lu R
Caldesmon基因（CALD 1）在细胞的许多功能中起着重要作用。有研究发现CALD 1表达与胃肠道肿瘤预后相关，但与肿瘤浸润淋巴细胞（TILs）的关系尚不清楚。通过Oncomine和肿瘤免疫评估资源（TIMER）数据库分析CALD 1在不同人类肿瘤中的表达。应用Kaplan-Meier曲线和基因表达谱交互分析（GEPIA）数据库分析CALD 1与不同类型肿瘤预后的关系。通过TIMER和GEPIA数据库进一步分析CALD 1表达与肿瘤免疫细胞浸润之间的关联。CALD 1在不同类型癌组织中的表达与癌旁正常组织有显著性差异。CALD 1的高表达与胃癌患者的总生存期（OS）相关，尤其是在N1、N2和N3期胃癌患者中。胃癌组织中CALD 1的表达与免疫浸润的CD 8 +T细胞、CD 4 +T细胞、巨噬细胞、中性粒细胞和树突状细胞（DCs）呈正相关。CALD 1在胃癌患者预后中起重要作用。胃癌组织中CALD 1的表达水平与免疫浸润密切相关。此外，CALD 1表达可能参与调节胃癌中的肿瘤相关巨噬细胞（TAMs）、树突状细胞、耗竭性T细胞和调节性T细胞。这些结果表明，CALD 1可以作为胃癌预后和免疫浸润的标志物。CALD 1在胃癌的免疫浸润中起重要作用。CALD 1对胃癌淋巴结转移患者的预后有一定影响。CALD 1在胃癌微环境中的免疫逃逸中起着至关重要的作用。CALD 1，免疫浸润，胃癌，微环境
Caldesmon gene (CALD1) plays an important role in many cellular functions. Some researchers have found the correlation between CALD1 expression and prognosis of gastrointestinal cancer (GI), but the association with tumor-infiltrating lymphocytes (TILs) still unclear. The expression of CALD1 in different human tumor was analyzed by Oncomine and Tumor Immune Estimation Resource (TIMER) databases. The correlations between CALD1 and prognosis in types cancer were explored by Kaplan–Meier plotter and Gene Expression Profiling Interactive Analysis (GEPIA) databases. The association between CALD1 expression and tumor immune cell infiltration was further analyzed via TIMER and GEPIA databases. The CALD1 expressions in types cancer between tumor tissues and adjacent normal tissues were significantly different. The high expression of CALD1 was related with poor overall survival (OS) of patients with gastric cancer, especially in gastric cancer patients at N1, N2 and N3 stages. The expression of CALD1 was positively associated with immune-infiltrated, such as CD8+T cells, CD4+T cells, macrophages, neutrophils, and dendritic cells (DCs) in gastric cancer. CALD1 was considerably a key role in prognosis of patients with gastric cancer. The expression level of CALD1 is significantly associated with immune-infiltrated in gastric cancer. Furthermore, CALD1 expression may be involved in regulating tumor-associated macrophages (TAMs), dendritic cells, exhausted T cells and regulatory T cells in gastric cancer. These findings suggest that CALD1 could be utilized as a marker of prognosis and immune infiltration in gastric cancer. CALD1 plays an important role in immune infiltration in gastric cancer. CALD1 can affect the prognosis in gastric cancer patients with lymph node metastasis. CALD1 plays a vital role in immune escape in the gastric cancer microenvironment. CALD1, immune infiltration, gastric cancer, microenvironment
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影响因子：
3.2
作者：
Waniczek D;Lorenc Z;Śnietura M;Wesecki M;Kopec A;Muc-Wierzgoń M
通讯作者：
Muc-Wierzgoń M
GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
影响因子：
4.7
作者：
Lim, Byungho;Park, Jong-Lyul;Kim, Seon-Young
通讯作者：
Kim, Seon-Young
通过生物信息学分析鉴定早发结直肠癌的潜在关键基因和通路
影响因子：
2.6
作者：
Zhao, Bin;Baloch, Zulqarnain;Zhao, Yilin
通讯作者：
Zhao, Yilin
影响因子：
45.3
作者：
Azimi, Farhad;Scolyer, Richard A.;Thompson, John F.
通讯作者：
Thompson, John F.