Maternal migraine and risk of pediatric cancers.
Maternal migraine and risk of pediatric cancers.
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DOI：
10.1002/pbc.30385
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发表时间：
2023-07
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
Maternal migraine has been linked to adverse birth outcomes including low birth weight and preterm birth, as well as congenital anomalies in offspring. It has been speculated that this may be due to the use of medications in pregnancy, but lifestyle, genetic, hormonal, and neurochemical factors could also play a role. There is evidence for varying cancer incidences among adults with migraine. Here, we utilized data from national registries in Denmark to examine associations between maternal diagnoses of migraine and risk for cancer in offspring. We linked several national registries in Denmark to identify cases from the Cancer Registry among children less than 20 years (diagnoses 1996–2016) and controls from the Central Population Register, matched to cases by birth year and sex (25:1 matching rate). Migraine diagnoses were identified from the National Patient Register using International Classification of Diseases, versions 8 and 10 codes and migraine-specific acute or prophylactic treatment recorded in the National Pharmaceutical Register. We used logistic regression to estimate the risk of childhood cancers associated with maternal migraine. Maternal migraine was positively associated with risk for non-Hodgkin lymphoma (odds ratio [OR] = 1.70, 95% confidence interval [CI]: 1.01–2.86), central nervous system tumors ([OR = 1.31, 95% CI: 1.02–1.68], particularly glioma [OR = 1.64, 95% CI: 1.12–2.40]), neuroblastoma (OR = 1.75, 95% CI: 1.00–3.08), and osteosarcoma (OR = 2.60, 95% CI: 1.18–5.76). Associations with maternal migraine were observed for several childhood cancers, including neuronal tumors. Our findings raise questions about the role of lifestyle factors, sex hormones, genetic, and neurochemical factors in the relationship between migraine and childhood cancers.
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影响因子：
7.4
作者：
Le, Han;Tfelt-Hansen, Peer;Olesen, Jes
通讯作者：
Olesen, Jes
影响因子：
45.3
作者：
Li, Christopher I.;Mathes, Robert W.;Prentice, Ross
通讯作者：
Prentice, Ross
影响因子：
1.1
作者：
BIRCH J M;HARTLEY A L;ET AL
通讯作者：
ET AL
影响因子：
158.5
作者：
HENDERSON, BE;GERKINS, V;PIKE, MC
通讯作者：
PIKE, MC
DOI：
10.1016/j.ejogrb.2006.08.025
发表时间：
2007-10-01
影响因子：
2.6
作者：
Banhidy, Ferenc;Acs, Nandor;Czeizel, Andrew E.
通讯作者：
Czeizel, Andrew E.