Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy.
Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy.
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作者：
细胞代谢紊乱是癌症的主要标志之一。癌细胞协调异常的新陈代谢重新编程以满足高能量需求。该综述集中于主要代谢途径、重要中间体和相关酶的机制，这些酶是由致癌过程改变的。重点放在以临床相关的代谢中间体为治疗目标，这些中间体对癌细胞的生存和增殖至关重要。因此，代谢途径、关键酶和中间体的临床干预在癌症治疗中提供了独特的利基。代谢重编程使癌细胞能够在缺乏营养的微环境和代谢废物的压力下增殖并产生肿瘤生物量。癌细胞巧妙地在代谢途径和代谢酶基因的差异表达方面经历了各种适应。代谢适应主要由来源癌细胞和宿主组织的生理需求决定。许多帮助癌细胞增殖的代谢调节因子包括葡萄糖代谢、脂肪酸、氨基酸代谢、核苷酸代谢、肿瘤抑制基因、microRNAs以及许多调节酶和基因的不受控制的合成/分解代谢。利用这一范式，我们回顾了目前对肿瘤代谢重编程的理解，并讨论了可用于癌症治疗的癌症代谢组学的新策略。
Deregulated cellular metabolism is one of the major hallmarks of cancer. Cancer cells orchestrate abnormal metabolic reprogramming to satisfy high energy demands. The review focuses on the mechanics of the major metabolic pathways, significant intermediates, and associated enzymes that are altered by the oncogenic progression. The emphasis is laid on therapeutically targeting clinically relevant metabolic intermediates which are crucial to cancer cell survival, and proliferation. The clinical intervention of metabolic pathways, critical enzymes, and the intermediate, thus offers a distinct niche in cancer therapies. Metabolic reprogramming enables cancer cells to proliferate and produce tumor biomass under a nutrient-deficient microenvironment and the stress of metabolic waste. A cancer cell adeptly undergoes a variety of adaptations in metabolic pathways and differential expression of metabolic enzyme genes. Metabolic adaptation is mainly determined by the physiological demands of the cancer cell of origin and the host tissue. Numerous metabolic regulators that assist cancer cell proliferation include uncontrolled anabolism/catabolism of glucose metabolism, fatty acids, amino acids metabolism, nucleotide metabolism, tumor suppressor genes, microRNAs, and many regulatory enzymes and genes. Using this paradigm, we review the current understanding of metabolic reprogramming in tumors and discuss the new strategies of cancer metabolomics that can be tapped into for cancer therapeutics.
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癌细胞对葡萄糖限制和双胍类药物敏感性的代谢决定因素。
影响因子：
64.8
作者：
Birsoy, Kivanc;Possemato, Richard;Lorbeer, Franziska K.;Bayraktar, Erol C.;Thiru, Prathapan;Yucel, Burcu;Wang, Tim;Chen, Walter W.;Clish, Clary B.;Sabatini, David M.
通讯作者：
Sabatini, David M.
DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
4.5
作者：
Chen JL;Lucas JE;Schroeder T;Mori S;Wu J;Nevins J;Dewhirst M;West M;Chi JT
通讯作者：
Chi JT
影响因子：
16.1
作者：
Chen, Yunching;Gao, Dong-Yu;Huang, Leaf
通讯作者：
Huang, Leaf
影响因子：
21.3
作者：
Boroughs LK;DeBerardinis RJ
通讯作者：
DeBerardinis RJ