Mass drug administration of ivermectin in south-eastern Senegal reduces the survivorship of wild-caught, blood fed malaria vectors.
Mass drug administration of ivermectin in south-eastern Senegal reduces the survivorship of wild-caught, blood fed malaria vectors.
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DOI：
10.1186/1475-2875-9-365
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发表时间：
2010-12-20
期刊：
影响因子：
3
通讯作者：
Foy BD
中科院分区：
文献类型：
--
作者：
Sylla M;Kobylinski KC;Gray M;Chapman PL;Sarr MD;Rasgon JL;Foy BD
在塞内加尔东南部，疟疾和盘尾丝虫病同时流行。用伊维菌素（IVM）每年1 ~ 2次大规模给药（MDA），15年来控制了该地区盘尾丝虫病。实验室饲养的冈比亚按蚊。虽然在摄入IVM后人体血液中发现的浓度下，IVM对伊维菌素敏感，但似乎可以在实地量化类似的效果，并且IVM作为疟疾控制工具可能具有益处。在2008年和2009年，野生捕获的血液喂养了安。冈比亚公司在IVM MDAs之前和之后，从三对塞内加尔村庄的小屋收集蚊子。将蚊子饲养在昆虫饲养室中以评估其存活率，随后鉴定其种属，并鉴定其血食。使用Glimmix模型对蚊子存活率的差异进行统计分析。最后，计算了IVM MDAs周围蚊子存活率的每日概率变化，并将这些数据插入先前开发的蚊子年龄结构疟疾传播模型中。冈比亚按蚊与对照村相比，处理村的阿拉伯按蚊（P = 0.0191）和疟疾（P <0.0001）的存活率显著降低。此外，An gambiae s.s.与对照村收集物相比，在处理村中在MDA后1-6天捕获的动物的存活率显著降低（P = 0.0003），与MDA前捕获的动物相比（P < 0.0001），与MDA后>7天捕获的动物相比（P < 0.0001）。在MDA之后的六天内，蚊子存活的每日概率下降>10%。疟疾传播的蚊子年龄结构模型表明，单次IVM MDA将使疟疾传播（Ro）降低至基线以下至少11天，重复IVM MDA将导致疟疾Ro持续降低。伊维菌素MDA可显著降低嗜水气单胞菌的存活率。冈比亚公司这足以暂时减少疟疾传播。在季节性传播的地区，反复进行病媒综合防治可能是一种新的综合性疟疾控制工具，并将对同一村庄被忽视的热带疾病产生同时影响。
In south-eastern Senegal, malaria and onchocerciasis are co-endemic. Onchocerciasis in this region has been controlled by once or twice yearly mass drug administration (MDA) with ivermectin (IVM) for over fifteen years. Since laboratory-raised Anopheles gambiae s.s. are susceptible to ivermectin at concentrations found in human blood post-ingestion of IVM, it is plausible that a similar effect could be quantified in the field, and that IVM might have benefits as a malaria control tool. In 2008 and 2009, wild-caught blood fed An. gambiae s.l. mosquitoes were collected from huts of three pairs of Senegalese villages before and after IVM MDAs. Mosquitoes were held in an insectary to assess their survival rate, subsequently identified to species, and their blood meals were identified. Differences in mosquito survival were statistically analysed using a Glimmix model. Lastly, changes in the daily probability of mosquito survivorship surrounding IVM MDAs were calculated, and these data were inserted into a previously developed, mosquito age-structured model of malaria transmission. Anopheles gambiae s.s. (P < 0.0001) and Anopheles arabiensis (P = 0.0191) from the treated villages had significantly reduced survival compared to those from control villages. Furthermore, An gambiae s.s. caught 1-6 days after MDA in treated villages had significantly reduced survival compared to control village collections (P = 0.0003), as well as those caught pre-MDA (P < 0.0001) and >7 days post-MDA (P < 0.0001). The daily probability of mosquito survival dropped >10% for the six days following MDA. The mosquito age-structured model of malaria transmission demonstrated that a single IVM MDA would reduce malaria transmission (Ro) below baseline for at least eleven days, and that repeated IVM MDAs would result in a sustained reduction in malaria Ro. Ivermectin MDA significantly reduced the survivorship of An. gambiae s.s. for six days past the date of the MDA, which is sufficient to temporarily reduce malaria transmission. Repeated IVM MDAs could be a novel and integrative malaria control tool in areas with seasonal transmission, and which would have simultaneous impacts on neglected tropical diseases in the same villages.
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影响因子：
64.8
作者：
CULLY, DF;VASSILATIS, DK;ARENA, JP
通讯作者：
ARENA, JP
DOI：
10.1179/000349809x12459740922138
发表时间：
2009-09-01
影响因子：
--
作者：
Fritz, M. L.;Siegert, P. Y.;Miller, J. R.
通讯作者：
Miller, J. R.
影响因子：
3.3
作者：
Gemperli, Armin;Sogoba, Nafomon;Vounatsou, Penelope
通讯作者：
Vounatsou, Penelope
影响因子：
2.1
作者：
Beier, JC
通讯作者：
Beier, JC
影响因子：
3.8
作者：
Brooker S;Hotez PJ;Bundy DA
通讯作者：
Bundy DA