HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility study.
HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility study.
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DOI：
10.1136/bmjopen-2022-066044
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发表时间：
2022-11-21
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
长期COVID（LC），又称COVID-19后综合征，是指COVID-19感染后症状持续12周。它影响多达七分之一的人感染这种疾病，并引起广泛的症状，包括疲劳，呼吸困难，心悸，头晕，疼痛和脑雾。这些症状中的许多可能与SARS-CoV 2感染后自主神经系统的自主神经功能障碍或失调有关。本研究旨在通过标准化缓慢呼吸程序测试心率变异性生物反馈（HRV-B）技术在LC患者中的可行性并评估其有效性。30名患有心悸或头晕症状以及NASA精益测试异常的成年LC患者将从长期COVID康复服务专家中选择。他们将使用连接至Elite HRV手机应用程序的Polar胸带设备接受为期4周的HRV-B干预，同时每周至少5天每天进行两次10分钟的呼吸锻炼技术。研究期间将使用以下方法收集定量数据：来自胸带和腕戴式Fitbit的HRV数据、改良的COVID-19约克郡康复量表、复合自主神经症状评分、WHO残疾评估量表和EQ-5D-5L健康相关生活质量指标。还将收集有关用户体验和在家庭环境中使用该技术的可行性的定性反馈。将使用相关性和显著性差异的标准统计检验分析定量数据。本研究已获得健康研究管理局（HRA）莱斯特南部研究伦理委员会的伦理批准（21/EM/0271）。传播计划包括学术和非专业出版物。NCT 05228665。
Long COVID (LC), also known as post-COVID-19 syndrome, refers to symptoms persisting 12 weeks after COVID-19 infection. It affects up to one in seven people contracting the illness and causes a wide range of symptoms, including fatigue, breathlessness, palpitations, dizziness, pain and brain fog. Many of these symptoms can be linked to dysautonomia or dysregulation of the autonomic nervous system after SARS-CoV2 infection. This study aims to test the feasibility and estimate the efficacy, of the heart rate variability biofeedback (HRV-B) technique via a standardised slow diaphragmatic breathing programme in individuals with LC. 30 adult LC patients with symptoms of palpitations or dizziness and an abnormal NASA Lean Test will be selected from a specialist Long COVID rehabilitation service. They will undergo a 4-week HRV-B intervention using a Polar chest strap device linked to the Elite HRV phone application while undertaking the breathing exercise technique for two 10 min periods everyday for at least 5 days a week. Quantitative data will be gathered during the study period using: HRV data from the chest strap and wrist-worn Fitbit, the modified COVID-19 Yorkshire Rehabilitation Scale, Composite Autonomic Symptom Score, WHO Disability Assessment Schedule and EQ-5D-5L health-related quality of life measures. Qualitative feedback on user experience and feasibility of using the technology in a home setting will also be gathered. Standard statistical tests for correlation and significant difference will be used to analyse the quantitate data. The study has received ethical approval from Health Research Authority (HRA) Leicester South Research Ethics Committee (21/EM/0271). Dissemination plans include academic and lay publications. NCT05228665.
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