The CMYA5 gene confers risk for both schizophrenia and major depressive disorder in the Han Chinese population
The CMYA5 gene confers risk for both schizophrenia and major depressive disorder in the Han Chinese population
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CMYA5基因增加中国汉族人群患精神分裂症和重度抑郁症的风险
DOI：
10.3109/15622975.2014.915057
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Shi Y
中科院分区：
文献类型：
--
作者：
Qiang Y;Ji J;Wang Y;Shi Y
抽象目标。最近的一项欧洲人群的全基因组关联研究（GWAS）表明CMYA 5基因与精神分裂症有关。先前的功能研究表明，CMYA 5蛋白可以与DTNBP 1和PKA相互作用，为CMYA 5在精神分裂症发病机制中的作用提供了进一步的支持。然而，这种关联需要在独立人群中进行额外的验证。方法.为了验证CMYA 5与精神分裂症和重性抑郁症之间的关联，我们对CMYA 5基因内的16个SNP进行了基因分型，并在1330名精神分裂症患者、1045名重性抑郁症患者和1235名正常对照中进行了病例对照研究。所有患者均为汉族。结果rs6883197和rs 259127与精神分裂症显著相关，rs 12514461、rs 259127和rs7343与重性抑郁障碍相关。此外，rs 16877109-rs3828611（G-G）的一个风险单倍型与精神分裂症（校正后P = 0.0000784）和重度抑郁症（校正后P = 0.00230）相关。结论.我们的研究结果支持CMYA 5中的特定等位基因和单倍型赋予中国汉族人群精神分裂症和抑郁症的遗传风险的观点。
Abstract Objectives. A recent genome-wide association study (GWAS) of the European population implicated the CMYA5 gene in schizophrenia. Previous functional studies showed that the CMYA5 protein can interact with DTNBP1 and PKA, providing further support for a role of CMYA5 in the pathogenesis of schizophrenia. However, this association requires additional validation in independent populations. Methods. To validate the association between CMYA5 and schizophrenia and major depressive disorder, we genotyped 16 SNPs within the CMYA5 gene and performed case–control studies in 1330 schizophrenia patients, 1045 patients with major depressive disorder, and 1235 normal controls. All patients were of Han Chinese origin. Results. rs6883197 and rs259127 were significantly associated with schizophrenia, and rs12514461, rs259127, and rs7343 were associated with major depressive disorder. Additionally, one risk haplotype of rs16877109–rs3828611 (G–G) was associated with both schizophrenia (P = 0.0000784, after correction) and major depressive disorder (P = 0.00230, after correction). Conclusions. Our findings support the idea that specific alleles and haplotype in the CMYA5 confer genetic risk for both schizophrenia and major depressive disorder in the Han Chinese population.
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影响因子：
44.1
作者：
Shi, YY;He, L
通讯作者：
He, L
DOI：
10.1523/jneurosci.5640-11.2012
发表时间：
2012-03-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gokhale A;Larimore J;Werner E;So L;Moreno-De-Luca A;Lese-Martin C;Lupashin VV;Smith Y;Faundez V
通讯作者：
Faundez V
影响因子：
4.8
作者：
Benson, MA;Tinsley, CL;Blake, DJ
通讯作者：
Blake, DJ
DOI：
10.1016/j.bbamcr.2007.04.004
发表时间：
2007-06-01
影响因子：
5.1
作者：
Reynolds, Joseph G.;McCalmon, Sarah A.;Naya, Francisco J.
通讯作者：
Naya, Francisco J.
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE