Decreased MALL expression negatively impacts colorectal cancer patient survival.
Decreased MALL expression negatively impacts colorectal cancer patient survival.
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MALL 表达减少会对结直肠癌患者的生存产生负面影响。
DOI：
10.18632/oncotarget.8094
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发表时间：
2016-04-19
期刊：
影响因子：
--
通讯作者：
Peng Z
中科院分区：
文献类型：
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作者：
Wang X;Fan J;Yu F;Cui F;Sun X;Zhong L;Yan D;Zhou C;Deng G;Wang B;Qi X;Wang S;Qu L;Deng B;Pan M;Chen J;Wang Y;Song G;Tang H;Zhou Z;Peng Z
本研究的目的是确定MALL表达是否与结肠癌进展和患者生存相关。与正常组织相比，70%的结肠癌患者和75%的直肠癌患者的肿瘤组织中MALL mRNA表达降低。MALL蛋白在结肠癌患者癌组织中的表达也明显降低（P <0.001）。与正常组织相比，在肿瘤组织中观察到MALL的洛缺失和甲基化增加。MALL表达降低与血管浸润、复发转移及死亡有关（P ≤ 0.027）。此外，MALL阴性肿瘤患者的总生存期（OS）和无病生存期（DFS）显著降低（分别为P <0.008和P <0.011）。单因素分析显示MALL表达与OS和DFS显著相关。最后，MALL的过表达抑制HCT 116和SW 480细胞的增殖，并抑制HCT 116的迁移。MALL可能在结直肠癌进展中发挥作用，因为抑制其在肿瘤组织中的表达会对结直肠癌患者的生存产生负面影响。需要进一步分析以确定MALL表达减少是否是由于洛缺失和/或甲基化。
The aim of the present study was to determine whether MALL expression is associated with colon cancer progression and patient survival. MALL mRNA expression was reduced in the tumor tissues of 70% of the colon cancer patients and 75% of the rectal cancer patients as compared to their normal tissues. MALL protein was also significantly reduced in the tumor tissues of colon cancer patients (P < 0.001). Increased LOH and methylation of MALL was observed in tumor tissues as compared to normal tissues. Reduced MALL expression was associated with vessin invasion, disease recurrence and metastasis or death (P ≤ 0.027). Furthermore, patients with MALL-negative tumors had significantly decreased overall survival (OS) and disease-free survival (DFS) (P < 0.008 and P < 0.011, respectively). Univariate analysis indicated that MALL expression was significantly associated with OS and DFS. Finally, overexpression of MALL suppressed HCT116 and SW480 cell proliferation and inhibited HCT116 migration. MALL may play a role in colorectal cancer progression as suppression of its expression in tumor tissues negatively impacts colorectal cancer patient survival. Further analyses are required to determine if reduced MALL expression is due to LOH and/or methylation.
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影响因子：
4.7
作者：
Nelson, R. Scott;Thorson, Alan G.
通讯作者：
Thorson, Alan G.
影响因子：
16
作者：
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通讯作者：
Posern, Guido
DOI：
10.1073/pnas.96.11.6241
发表时间：
1999-05-25
影响因子：
11.1
作者：
Cheong, KH;Zacchetti, D;Simons, K
通讯作者：
Simons, K
影响因子：
4.3
作者：
Li, Ming;Gu, Jin
通讯作者：
Gu, Jin
影响因子：
8.8
作者：
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