Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.
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DOI：
10.1002/cphy.c110062
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发表时间：
2013-01
影响因子：
5.8
通讯作者：
Barnard RJ
中科院分区：
文献类型：
--
作者：
Roberts CK;Hevener AL;Barnard RJ
代谢综合征（MS）是一组心脏代谢危险因素，包括肥胖、胰岛素抵抗、高血压和血脂异常。虽然关于该综合征的标准和概念存在重大争议，但这种风险因素的聚集与发展2型糖尿病和心血管疾病的风险增加明确相关。不管真正的定义是什么，根据目前的人口估计，近1亿人患有MS。它通常以胰岛素抵抗为特征，有些人认为这是缺乏体力活动和MS之间的主要基础联系。（i）提供MS的历史、原因和临床方面的概述，（ii）回顾胰岛素作用的分子机制和胰岛素抵抗的原因;（iii）讨论运动对MS和胰岛素敏感性影响的流行病学和干预数据。
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia. Although there has been significant debate regarding the criteria and concept of the syndrome, this clustering of risk factors is unequivocally linked to an increased risk of developing type 2 diabetes and cardiovascular disease. Regardless of the true definition, based on current population estimates, nearly 100 million have MS. It is often characterized by insulin resistance, which some have suggested is a major underpinning link between physical inactivity and MS. The purpose of this review is to: (i) provide an overview of the history, causes and clinical aspects of MS, (ii) review the molecular mechanisms of insulin action and the causes of insulin resistance, and (iii) discuss the epidemiological and intervention data on the effects of exercise on MS and insulin sensitivity.
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