Feature-Based Visual Short-Term Memory Is Widely Distributed and Hierarchically Organized.
Feature-Based Visual Short-Term Memory Is Widely Distributed and Hierarchically Organized.
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DOI：
10.1016/j.neuron.2018.05.026
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发表时间：
2018-07-11
期刊：
影响因子：
16.2
通讯作者：
Gray, Charles M.
中科院分区：
文献类型：
--
作者：
Dotson, Nicholas M.;Hoffman, Steven J.;Goodell, Baldwin;Gray, Charles M.
以视觉为基础的短期记忆是由感觉皮层和联想皮层共同参与的。然而，参与回路的范围和记忆维持的神经机制仍然是一个激烈的争论。为了解决这些问题，我们记录了猴子42个皮层区域的神经元活动，这些猴子执行基于特征的视觉短期记忆任务和交错固定任务。我们发现，任务依赖性的放电率的差异广泛分布在整个皮层，而刺激特定的变化，放电率更受限制和层次组织。我们还表明，在记忆延迟期间的微扫视编码的刺激在内存中，由微扫视调制的单位更有可能表现出刺激的特异性，这表明眼球运动有助于视觉短期记忆过程。这些结果支持了一个框架，其中大多数皮层区域，在一个模态，有助于记忆表征的时间尺度，增加沿着皮层层次。Dotson等人记录了猴子执行基于特征的记忆任务的42个皮层区域。他们发现，任务依赖性的放电率差异分布广泛，而刺激特定的放电率变化更受限制和层次组织。
Feature-based visual short-term memory is known to engage both sensory and association cortices. However, the extent of the participating circuit and the neural mechanisms underlying memory maintenance is still a matter of vigorous debate. To address these questions, we recorded neuronal activity from 42 cortical areas in monkeys performing a feature-based visual short-term memory task and an interleaved fixation task. We find that task-dependent differences in firing rates are widely distributed throughout the cortex, while stimulus-specific changes in firing rates are more restricted and hierarchically organized. We also show that microsaccades during the memory delay encode the stimuli held in memory and that units modulated by microsaccades are more likely to exhibit stimulus specificity, suggesting that eye movements contribute to visual short-term memory processes. These results support a framework in which most cortical areas, within a modality, contribute to mnemonic representations at timescales that increase along the cortical hierarchy. Dotson et al. recorded from 42 cortical areas in monkeys performing a feature-based memory task. They find that task-dependent differences in firing rates are widely distributed, while stimulus-specific changes in firing rates are more restricted and hierarchically organized.
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DOI：
10.1093/cercor/bhs270
发表时间：
2014-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Markov NT;Ercsey-Ravasz MM;Ribeiro Gomes AR;Lamy C;Magrou L;Vezoli J;Misery P;Falchier A;Quilodran R;Gariel MA;Sallet J;Gamanut R;Huissoud C;Clavagnier S;Giroud P;Sappey-Marinier D;Barone P;Dehay C;Toroczkai Z;Knoblauch K;Van Essen DC;Kennedy H
通讯作者：
Kennedy H
影响因子：
25
作者：
Mendoza-Halliday D;Torres S;Martinez-Trujillo JC
通讯作者：
Martinez-Trujillo JC
影响因子：
3
作者：
Asaad, Wael F.;Eskandar, Emad N.
通讯作者：
Eskandar, Emad N.
影响因子：
19.9
作者：
Luck SJ;Vogel EK
通讯作者：
Vogel EK
影响因子：
16.2
作者：
Dotson, Nicholas M.;Hoffman, Steven J.;Gray, Charles M.
通讯作者：
Gray, Charles M.