A weighted and directed interareal connectivity matrix for macaque cerebral cortex.
A weighted and directed interareal connectivity matrix for macaque cerebral cortex.
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DOI：
10.1093/cercor/bhs270
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Kennedy H
中科院分区：
文献类型：
--
作者：
Markov NT;Ercsey-Ravasz MM;Ribeiro Gomes AR;Lamy C;Magrou L;Vezoli J;Misery P;Falchier A;Quilodran R;Gariel MA;Sallet J;Gamanut R;Huissoud C;Clavagnier S;Giroud P;Sappey-Marinier D;Barone P;Dehay C;Toroczkai Z;Knoblauch K;Van Essen DC;Kennedy H
对猕猴大脑皮层 91 个区域中的 29 个区域进行逆行示踪剂注射，揭示了 1,615 个区域间通路，其中三分之一以前从未报道过。确定每个区域到区域路径的权重指数（标记神经元的外在分数 [FLNe]）。与已知的预测相比，新发现的预测平均较弱；然而，这两组路径的权重分布存在广泛重叠。在给定 FLNe 值范围（标准差 <1 个对数单位，范围 5 个对数单位）的情况下，个体之间的重复注射显示出适度的 FLNe 变异性。每个区域的连通性分布符合对数正态分布，其中大多数预测的强度中等或较弱。在 G29 × 29 区域间子图中，可以存在的连接的三分之二确实存在。对从 G29 × 91 子图的所有 91 个节点收集链接的最小区域集的分析（支配集分析）证实了皮质矩阵的密集（66％）结构。 G29 × 29 子图表明单向链接的发生率出乎意料地高。猕猴的有向加权 G29 × 91 连接矩阵对于与包括人类在内的其他物种的连接分析进行比较很有价值。它还将为未来探索皮质网络规律的建模研究提供信息。
Retrograde tracer injections in 29 of the 91 areas of the macaque cerebral cortex revealed 1,615 interareal pathways, a third of which have not previously been reported. A weight index (extrinsic fraction of labeled neurons [FLNe]) was determined for each area-to-area pathway. Newly found projections were weaker on average compared with the known projections; nevertheless, the 2 sets of pathways had extensively overlapping weight distributions. Repeat injections across individuals revealed modest FLNe variability given the range of FLNe values (standard deviation <1 log unit, range 5 log units). The connectivity profile for each area conformed to a lognormal distribution, where a majority of projections are moderate or weak in strength. In the G29 × 29 interareal subgraph, two-thirds of the connections that can exist do exist. Analysis of the smallest set of areas that collects links from all 91 nodes of the G29 × 91 subgraph (dominating set analysis) confirms the dense (66%) structure of the cortical matrix. The G29 × 29 subgraph suggests an unexpectedly high incidence of unidirectional links. The directed and weighted G29 × 91 connectivity matrix for the macaque will be valuable for comparison with connectivity analyses in other species, including humans. It will also inform future modeling studies that explore the regularities of cortical networks.
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影响因子：
2.4
作者：
Barbas H;Hilgetag CC;Saha S;Dermon CR;Suski JL
通讯作者：
Suski JL
早期视觉皮层中额叶信号的自下而上的门控。
DOI：
10.1126/science.1153276
发表时间：
2008-07-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ekstrom LB;Roelfsema PR;Arsenault JT;Bonmassar G;Vanduffel W
通讯作者：
Vanduffel W
影响因子：
5.7
作者：
Behrens TE;Sporns O
通讯作者：
Sporns O
影响因子：
2.5
作者：
BOUSSAOUD, D;DESIMONE, R;UNGERLEIDER, LG
通讯作者：
UNGERLEIDER, LG
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.