Comparison of pharmacy-based measures of adherence to antiretroviral therapy as predictors of virological failure.
Comparison of pharmacy-based measures of adherence to antiretroviral therapy as predictors of virological failure.
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将基于药房的依从性抗逆转录病毒疗法作为病毒学衰竭的预测指标的比较。
DOI：
10.1007/s10461-014-0953-2
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发表时间：
2015-04
影响因子：
4.4
通讯作者：
Van Rie, Annelies
中科院分区：
文献类型：
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作者：
Henegar, Cassidy E.;Westreich, Daniel;Maskew, Mhairi;Brookhart, M. Alan;Miller, William C.;Majuba, Pappie;Van Rie, Annelies
我们比较了多种基于药房再填充的抗逆转录病毒治疗依从性指标，以及基于预测病毒学失败能力的定义非依从行为的阈值。在南非约翰内斯堡的一家大型诊所就诊的8，695名患者共提供了29，937次药房就诊和相应的病毒载量评估。使用最严格的依从性阈值[100%药丸覆盖率：比值比（OR）（95%置信区间（CI））：1.26（1.15，1.39）;在计划的补充日期或之前服用处方药：1.27（1.16，1.38）]，基于药丸覆盖率和补充服用时间的指标进行了验证。对于这两种类型的指标，不遵守和病毒学失败之间的关联增加的阈值定义的遵守行为降低。所有测量均显示出高特异性（范围84 - 98%），但低灵敏度（5 - 19%）。在这种情况下，使用基于药物的指标确定为不依从的患者可能被正确分类，并且需要干预以提高依从性。然而，仅基于药房的措施不足以识别大多数不依从病例。
We compared multiple pharmacy refill-based adherence indicators for antiretroviral therapy, as well as thresholds for defining non-adherent behavior, based on ability to predict virological failure. A total of 29,937 pharmacy visits with corresponding viral load assessments were contributed by 8,695 patients attending a large clinic in Johannesburg, South Africa. Indicators based on pill coverage and timing of refill pickup performed comparably using the strictest thresholds for adherence [100 % pill coverage: odds ratio (OR) (95 % confidence interval (CI)) : 1.26 (1.15, 1.39); prescription picked up on or before scheduled refill date: 1.27 (1.16,1.38)]. For both types of indicators, the association between non-adherence and virological failure increased as the threshold defining adherent behavior was lowered. All measures demonstrated high specificity (range 84–98 %), but low sensitivity (5–19 %). In this setting, patients identified as non-adherent using pharmacy-based indicators are likely correctly classified and in need of interventions to improve compliance. Pharmacy based measures alone, however, are inadequate for identifying most cases of nonadherence.
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DOI：
10.1097/00042560-200205010-00014
发表时间：
2002-05-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
影响因子：
--
作者：
de Olalla, PG;Knobel, H;Caylà, JA
通讯作者：
Caylà, JA
影响因子：
7.7
作者：
Fox, Matthew P.;Maskew, Mhairi;Sanne, Ian M.
通讯作者：
Sanne, Ian M.
影响因子：
5
作者：
Pepe, MS;Janes, H;Newcomb, P
通讯作者：
Newcomb, P
影响因子：
158.5
作者：
Riddler, Sharon A.;Haubrich, Richard;Mellors, John W.
通讯作者：
Mellors, John W.
影响因子：
4.6
作者：
Grossberg, Robert;Gross, Robert
通讯作者：
Gross, Robert