The impact of ageing on natural killer cell function and potential consequences for health in older adults.
The impact of ageing on natural killer cell function and potential consequences for health in older adults.
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DOI：
10.1016/j.arr.2013.04.003
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发表时间：
2013-09
影响因子：
13.1
通讯作者：
Lord, Janet M.
中科院分区：
文献类型：
--
作者：
Hazeldine, Jon;Lord, Janet M.
自然杀伤（NK）细胞的作用正在显现，超出了去除转化细胞的范围。这些包括免疫调节和消除衰老细胞。人类衰老与NK细胞功能下降有关。我们提出人类衰老的某些方面部分是由于NK细胞功能下降。这些包括疫苗接种效力降低和炎症消退延迟。自然杀伤（NK）细胞是天然免疫系统的关键效应细胞，是抵御病毒感染和恶性细胞的第一道防线。随着年龄的增长，NK细胞提供宿主保护的两种主要机制已报告出现显著损害：直接细胞毒性和免疫调节细胞因子和趋化因子的分泌。在老年受试者中，NK细胞活性降低已被证明与病毒感染的发病率和严重程度增加相关，突出了年龄相关的NK细胞生物学变化对老年人健康的临床意义。然而，对病毒感染的易感性增加是NK细胞功能的这些年龄相关变化的唯一后果吗？最近，已经出现的证据表明，除了消除转化的细胞之外，NK细胞还参与许多其他生物过程，例如免疫调节、抗微生物免疫应答以及衰老细胞的识别和消除、涉及NK介导的细胞毒性和/或细胞因子产生的新功能。因此，伴随生理衰老的NK细胞功能下降可能对老年人的健康产生比最初想象的更广泛的影响。在这里，我们详细描述了NK细胞生物学的变化，伴随着人类的衰老，并提出衰老过程中的某些特征，如：（i）增加的再激活率的潜伏性结核分枝杆菌，（ii）炎症反应的解决速度较慢，（iii）增加的细菌和真菌感染的发病率部分归因于年龄相关的NK细胞功能下降。
Roles are emerging for natural killer (NK) cells beyond removing transformed cells. These include immune regulation and the elimination of senescent cells. Human ageing is associated with a decline in NK cell function. We propose some aspects of human ageing are due in part to reduced NK cell function. These include reduced vaccination efficacy and delayed resolution of inflammation. Forming the first line of defence against virally infected and malignant cells, natural killer (NK) cells are critical effector cells of the innate immune system. With age, significant impairments have been reported in the two main mechanisms by which NK cells confer host protection: direct cytotoxicity and the secretion of immunoregulatory cytokines and chemokines. In elderly subjects, decreased NK cell activity has been shown to be associated with an increased incidence and severity of viral infection, highlighting the clinical implications that age-associated changes in NK cell biology have on the health of older adults. However, is an increased susceptibility to viral infection the only consequence of these age-related changes in NK cell function? Recently, evidence has emerged that has shown that in addition to eliminating transformed cells, NK cells are involved in many other biological processes such as immune regulation, anti-microbial immune responses and the recognition and elimination of senescent cells, novel functions that involve NK-mediated cytotoxicity and/or cytokine production. Thus, the decrease in NK cell function that accompanies physiological ageing is likely to have wider implications for the health of older adults than originally thought. Here, we give a detailed description of the changes in NK cell biology that accompany human ageing and propose that certain features of the ageing process such as: (i) the increased reactivation rates of latent Mycobacterium tuberculosis, (ii) the slower resolution of inflammatory responses and (iii) the increased incidence of bacterial and fungal infection are attributable in part to an age-associated decline in NK cell function.
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影响因子：
9.2
作者：
Chinnaiyan, AM;Hanna, WL;Dixit, VM
通讯作者：
Dixit, VM
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
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影响因子：
20.3
作者：
Fauriat, Cyril;Long, Eric O.;Bryceson, Yenan T.
通讯作者：
Bryceson, Yenan T.
影响因子：
15.1
作者：
Bigley, Austin B.;Lowder, Thomas W.;Simpson, Richard J.
通讯作者：
Simpson, Richard J.
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
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